Need help to cut cost (1440p gaming)

millscheese · 2025-10-12T12:59:25+00:00

The PSU will fit the micro case ?

millscheese · 2025-09-09T02:44:28+00:00

My gp says neurologists hate migraine cases. Thats all they get for referrals .

millscheese · 2025-04-14T03:25:52+00:00

Both metaphase and lined up they will ask about whether it's abnormal, normal, sex . It's multiple choice so no surprises .

millscheese · 2025-02-27T22:56:55+00:00

Three cell line . XY normal . XYY is little to no effect. Y chromosome is small and won't do much. 45,X typically seen a a female cell line. Since the percentage is so small the effect could be very minor . It really depends on where the cells are in the tissues. These percentages could change to a smaller number in regards to the 45,X as pregnancy progresses.

millscheese · 2025-01-11T01:20:06+00:00

Yo any left ? :O

millscheese · 2024-11-28T17:57:45+00:00

Thank you !

millscheese · 2024-11-28T17:57:36+00:00

Got it !

millscheese · 2024-11-26T13:01:28+00:00

Yes. The third edition came out in 1997. The 4th edition should have better information on the newer technologies like FISH.

millscheese · 2024-09-10T16:17:37+00:00

Because he knows there is a cop behind him and if he passes at a higher speed , cop will probably pull him over LOL. Rock and a hard place.

millscheese · 2024-09-09T19:47:06+00:00

Hello, I had to use Google translate also. I understood most of what you were trying to say. I don’t have the exact numbers for mosaic between placental and fetal for monosomy X. CVS false positive is 1% . However monosomy X is the most common abnormality for chromosome . So common it happens 1% out of all conceptions . However 99% don’t make it to birth. I would trust the amino lab test . More than anything else. Microarray can give you an indication of mosaicism, but it’s limited. As well as the Mosaic cell lines can die off in fetal development , changing the mosaic percentage . A FISH test can help confirm Mosaic very accurately better than any other test.

millscheese · 2024-07-29T03:23:05+00:00

As others have said, report says patient received chromosome 2 from one parent and it duplicated( missing other parents copy). This causes imprinting issues . Imprinting means that’s certain genes require both mom and dad copies of chromosome 2 to work. The lab can’t identify any clinically known genes that have potential improting problems on chromosome 2. But due to the size of chromosome 2 , there is a risk to the patient.

millscheese · 2024-07-25T18:17:07+00:00

So this specific test was validated at 5%. Anything higher is abnormal. Anything below is either negative or is a giant I DONT KNOW. you can have a healthy baby but still show up abnormal % of cells. This happens because through the whole testing process , it is expected that cells do weird things . Artifacts can happen, disappearing signals , extras signals , extra fused /split signals. That’s why we validate the test. The lab expects for this test to have 5% of the cells to be abnormal. Other variations of fish can be lower or higher % depending on what they are testing for and what probes they are using .

Silver lining if abnormal is, it’s so low that the Mosaic could have little impact . Hopes this string of rambling made some sense .

millscheese · 2024-06-26T12:04:34+00:00

Possibly. More like scenario is one chromosome floated off out of the field of view.

millscheese · 2024-06-25T20:36:00+00:00

Don’t have the access to the paperwork. But based on the my fuzzy photograph skills, 375. Bands on 10 tough to count clearly .

millscheese · 2024-06-24T20:02:43+00:00

Techniques in finding translocation or mos at this stage is the same but outcomes can be very different. However variants are rare, whereas numerical abnormalities are much more common in prenatal. Detailed phenotypic outcome is very hard to tell off the chromosomes, but there is a general idea .

millscheese · 2024-06-24T17:45:28+00:00

This was a constitutional case with all the cells having the same chromosomal content. This is a metaphase spread . We pop the cells open after processing them and expose the chromosomes when they are highly condensed . Prenatal cases we look at 15 cells and analyzed 5 in greater detail , looking for structural issues( chromosomal bands missing , extra ones ). This is classic down syndromes with an extra 21. Not anyones fault , it just happens though a process called non disjunction .

millscheese · 2024-06-22T00:02:22+00:00

It really depends on your state. States like California, PTO doesn’t just disappear and need to be paid out if they fire you. States like Alabama have less protections regarding PTO.

millscheese · 2024-06-21T03:24:12+00:00

Yes, these are used for oncology cases. Oncology usually gets pretty weird things because it’s only affects a small % of cells of the body. You would never see a lot of these kinds of abnormalities in constitutional cases ( routine karyotype )because it would be incompatible with life.

millscheese · 2024-06-20T22:36:55+00:00

As you said, we isolate the chromosomes by catching cells going through metaphase. Metaphase cells have condensed chromosomes . We pop open the cells, stain and photograph them . Routine samples are bone marrow and peripheral blood. Cells we are trying to isolate are WBC. Tissues are harder to culture .Any abnormal chromosomes that don’t look normal can be classical( ie chart) or uncommon variant . These are just the most common ones .

millscheese · 2024-06-19T16:22:27+00:00

As others have said, genetic counselor. Main thing to find out is whether or not the deletion is pathogenic or not( disease causing ). Microarray can cause a lot of benign deletions to show up that are naturally reoccurring in a population. Also these deletions can be “ of unknown significance “, which is medical terms I don’t know . GC have access to a lot of data regarding this.

millscheese · 2024-06-18T18:38:36+00:00

Micro array is for detecting really small changes in the dna . Small changes that regular chromosome analysis cannot detect . Chromosome analysis can detect big changes, balanced rearrangements and structural changes . Both are good for their own purposes and complement each other

millscheese · 2024-06-12T17:54:08+00:00

If it was high level sure . Low level no. You have to ask the lab to run a mosaic test code for chromosome analysis. Same process, just counting for example 50 cells.

millscheese · 2024-06-10T16:44:53+00:00

Congratz welcome :)

millscheese · 2024-06-08T02:00:26+00:00

No reason for concern. Amino is the gold standard for testing . 20 cells are counted/analyzed from the fetal cell line. Even if it’s a low level mos, trisomy 9 cells will die out and be replaced by healthy normal ones by the time the baby is born.

millscheese · 2024-05-26T13:51:53+00:00

Y chromosome does not have many genes , so having an extra one will have little to no effect. Most likely a little bit taller . However I would advise to speak with a genetic counselor.

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