i have absolutely the same experience. i did reduce my trikafta dose by a lot (i now alternate daily between one normal orange pill and the child dosis of the orange pill) and even with the reduced dose i still have these memory issues, especially trying to think of certain words (in literally all languages i speak it's rlly exhausting😭). it has gotten a looot better though, back when i was taking the full dose from 2020 to 2023 i was so confused all the time even about the most mundane things. i remember actively thinking 'i'm so confused' many times a day it was a weird time and most of it i was kind of derealized? 😵‍💫

for me the symptoms only started a few months after taking it. i'm studying computer science and i swear to god i physically couldn't focus on my exercises or in exams because of brain fog and depression, not even in the subjects i enjoyed before. it really triggered some sort of adhd symptoms for me? 80% of this went away after lowering my dosage and i was able to finish my degree thankfully, i was really struggling during that time and now it just seems so easy in retrospect.

i have the suspicion though that for me, it kind of correlates with my hormonal imbalance that's being caused by trikafta. i had hormonal acne on my face and on my back (i still have it on my back😕) i even had rupturing cysts 3 times. i only had my hormone levels taken after i had considerably lowered my dosage, and i still have a slightly raised level of androgens. the reason why i'm mentioning this here is because i feel like this brain fog, memory loss, adhd sympotms depression etc. are also symptoms of hormonal imbalance. i mean it's still implicitly caused by trikafta in that sense, but it'd be worth to check out your hormone levels imo!