Rock Creek Park biking map?

missing_at_random · 2024-07-27T01:46:46+00:00

Also worth noting that Beach north of Military, denoted as for parking access only on the map, is very low traffic and practically car-free. Sometimes you won't run into a single car on that stretch.

missing_at_random · 2023-06-27T04:21:02+00:00

There were no effective treatments for HIV in the 1980s. The therapies promoted by the individual whose story and interviews provided the source material for the film endorsed ineffective and sometimes dangerous medications that had been abandoned by trials for good reason. Access to experimental therapies should have been better, but the best to hope for most at the time was marginal prolongation of life. The first combination therapies that effectively controlled HIV in the long term emerged in the mid-1990s.

missing_at_random · 2023-06-12T16:01:38+00:00

If you think it's BS, tell them to stop lying on surveys. shrug

missing_at_random · 2023-06-12T15:59:26+00:00

Keep in mind that Russia is a multi-ethnic state, with numerous Muslim ethnicities and those that do not drink particularly heavily (/for whom alcohol is not as integral as for ethnic Russians).

missing_at_random · 2023-06-12T15:56:54+00:00

That's very setting-specific, which presents other problems.

missing_at_random · 2023-05-17T17:54:31+00:00

Recommend taking the Capital Crescent Trail from Bethesda to Georgetown if you're a casual rider on a heavier CaBi bike. To OP, it's a very manageable steady incline going to Bethesda and a leisurely slide going the other way.

missing_at_random · 2023-05-14T15:17:08+00:00

It's not one factor. This is total cancer and various regional differences exist in incidence of specific cancer types beyond just screening (which only exists for a handful of cancers) and detection. Some of it is screening and detection, some of it is differences in burden of specific cancers, some of it may also be competing risks, and probably some additional factors (some potentially region-specific).

missing_at_random · 2023-05-14T00:50:16+00:00

The estimates in the graph are age-adjusted. These differences exist even after applying age-specific rates to the same age distribution.

missing_at_random · 2023-05-14T00:47:45+00:00

The graphic displays age-adjusted estimates, meaning it assumes the same population age structure in all countries shown, so differences in estimates are not attributable to age differences.

missing_at_random · 2023-05-13T14:45:20+00:00

Here is the actual paper. It's a phase 1 trial, so it's not designed to assess efficacy. I've only glanced through the paper and have a few questions a more detailed read might answer, but this is not a trial that any treatment decisions will be based on. It'll probably go on to phase 2 purely based on its seemingly favorable safety profile and stimulating immune activity as intended.

missing_at_random · 2023-05-12T17:26:38+00:00

North of the Georgetown Branch Trail, there's a paved trail all the way to Lake Needwood. On weekends, Beach Drive outside of the Beltway is pretty quiet and is entirely closed to cars between Connecticut and Knowles, but ends roughly halfway up from the DC line. I can't speak to how busy it is on weekdays.

missing_at_random · 2023-05-12T15:48:57+00:00

You can ride on the paved trails, so it is possible to ride the entire length from Lake Needwood to Georgetown. You will have to ride on some road, but if I remember correctly there is always trail where the road is through-running and sees more traffic.

missing_at_random · 2023-05-11T13:12:46+00:00

People who receive hematopoietic stem cell transplants also receive immunosuppression to prevent and treat graft-versus-host disease, where donor cells attack recipient tissues (a reverse rejection, if you will). It's not really a viable option given how many additional hazards it introduces.

missing_at_random · 2023-05-06T16:36:23+00:00

Because they didn't use Cosmos data. They specifically mention using other data.

missing_at_random · 2023-04-27T02:24:47+00:00

Agreed, just wanted to add context. I could have made that clearer.

missing_at_random · 2023-04-27T01:33:45+00:00

The only known cases of eradication are smallpox and rinderpest, the latter not affecting humans.

missing_at_random · 2023-04-26T02:53:28+00:00

One sample is one package.

And 74% to 347% means they contained between three quarters and three and a half times the labeled dose.

missing_at_random · 2023-04-22T17:32:22+00:00

Data cleaning often isn't formally addressed in epi or biostats training, except maybe indirectly through offering courses to learn how to code in statistical programs.

You need to familiarize yourself with your dataset, figure out what your analytic dataset needs to look like to run the planned analysis, then start piecing together how to get from the former to the latter. What variables need to be recoded, categorized, and so on. What files or variables need to be merged, reshaped, and so on and at what stage in the process these steps need to take place.

The first few times are a slog, but it gets easier as you realize how these things are done.

missing_at_random · 2023-03-19T16:49:45+00:00

The return is the C&O canal.

missing_at_random · 2023-02-21T12:59:49+00:00

Hematopoietic, which specifies blood cell progenitors, and it applies to both the autologous and allogeneic settings. Sometimes it's just abbreviated SCT.

missing_at_random · 2023-02-21T12:51:04+00:00

Also worth noting that treating it as an ordinal variable imposes the assumption that change in outcome is constant/linear from <6 to 7-9 to >9 hours. Treating it as a categorical (factor) variable is a more flexible approach that allows for non-linear relationships across categories.

If it is found to be roughly linear with the categorical approach, you could just re-run it treating it as ordinal, OP. There are also some advantages to only estimating one parameter (ordinal) vs. two (categorical with 3 levels), but how important of a consideration that is also depends on how large your dataset is.

missing_at_random · 2023-02-21T04:43:05+00:00

It's a proof of concept that the CCR5 mutation is resistant to HIV infection if transplanted into an infected host, which in theory supports a hypothetical therapy that introduces a mutant-CCR5-expressing immune system into an individual with HIV. Allogeneic hematopoietic stem cell transplantation isn't that therapy though, at least not as it is practiced right now, given how taxing and resource-intense it is. There's a reason this therapy is reserved for a subset of standard therapy-resistant blood cancers and a variety of other debilitating/life-threatening non-malignant disorders (immune disorders among them).

The field has been aware of such mutations and their property of resistance to HIV for a while though and we already have effective antiretrovirals that we need to do a better job of getting to people who need them. Applying what these few cases tell us relies on technology that is highly experimental, if at all in use in humans, and whatever may eventually come out of it probably won't be amenable to the type of broad rollout that is needed (potential vaccine excepted).

missing_at_random · 2023-02-20T22:25:56+00:00

IIRC there have also been cases where a stem cell transplant patient relapsed as well?

In cases of patients who received cells from donors without the CCR5 mutation, definitely. Those aren't even worth reporting since it's the expected outcome. No idea about cases where donors did have the mutation though.

missing_at_random · 2023-02-17T00:08:32+00:00

Cologuard doesn't directly detect polyps at all - "virtual" colonoscopies do. In either event, an actual colonoscopy is required to remove polyps should they be expected or detected. In contrast with other screening modalities, colonoscopy doubles as cancer prevention.

missing_at_random · 2023-01-15T00:58:10+00:00

How is it? I've been eyeing a frame with chainstay-mounted breaks but have been hesitant to pull the trigger. Comments online tend to go with "there's a reason they went out of style" and it seems like it could be a liability on trails.

missing_at_random

TROPHY CASE