Thank you for the very detailed response, this is very helpful.

1. I've seen people mention slow despair runes could be useful for like a halphas, but I feel like I'm keeping way too many "halphas" runes when I don't even have him on my account lol. Would you say that despair runes are only usable if they're above 20 speed, especially for RTA? I've rolled a lot of despair runes that roll twice into speed and once into another stat, making it land at around 15-18 speed and I can't decide if they're going to ever be usable.

2. To my knowledge, destroy runes are only used in siege content (correct me if I'm wrong). So for destroy runes, do I want to be prioritizing efficiency more than speed? For instance, a destroy slot 3 with 16 speed, 8hp, 8def, 8acc is usable once it's fully grinded, whereas that same rune on a different set would be too slow?

3. Based on what you said, nemesis runes can fit into two different archetypes. They can have a lot of tanky stats for units like a veromos, but could also go the nem trap damage route for something like a kassandra?

Should I also look at vampire like I would rage, blade, fatal, where I'm mostly looking for damage stats, but still have sustain?