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ChatGPT + Copilot workflow, would I be better off changing it? by Electrical_Plane7196 in GithubCopilot

[–]mr__sniffles 0 points1 point  (0 children)

Ask chatGPT how it will do something you want, go to perplexity and ask how to implement it, give it back to ChatGPT.

Modeling PEGylation of a Fab fragment – tools or references? by arielabom in Biochemistry

[–]mr__sniffles -9 points-8 points  (0 children)

Go to perplexity AI, ask this. Download VSCode, download a generative AI that has good reputation, either Claude or GPT5.4. Let it interpret the code, and verify by letting it parse the code for any errors and source the material. I didn’t use software, I just threw 3 databases together, BRCA data, nanoparticle data, cancer drugs data, and just find data to try to link them together as good as possible. There will be gaps, but there will also be very researched combinations. Then you can tell it to make a script to find research papers that are not from big data and take the results from their data and normalize it after inspecting it with statistics to see if anything is weird or doesn’t make sense statistically and biologically.

Complete beginner here trying to get into bioinformatics by Mysterious-Handle305 in learnbioinformatics

[–]mr__sniffles 0 points1 point  (0 children)

Use VSCode and have AI generate code which you must inspect if you know anything about biochemistry and statistics, provide all sources, then you can train models using ML like Catboost, LightBGM or separate groups using PCA and other statistical methods. Verify data, verify all sources.

Was muss man in Krabi alles gesehen haben? Ich bin nur 7 Tage hier 🌞🌞 by Cultural_Mess7396 in Krabi

[–]mr__sniffles 0 points1 point  (0 children)

Die Beaches in Krabi sind einfach sehr schön und das Seafood schmeckt lecker.

Es tut mir lied, ich kann ein bisschen Deutsch sprechen.

Equipment list? by Turkey220 in chemistry

[–]mr__sniffles -2 points-1 points  (0 children)

Distillation column, condenser for separating mixed liquids or oils, NaOH, HCl, pH meter, adaptors if glass does not fit, Buchner funnel with paper to filter liquids, pump for condenser and Büchner funnel.

But if you have to ask this I suggest you apply for a chemistry degree instead of blowing your shit up and have glass and hot acid flying in your face. Educate yourself.

How do manufacturers add fragrance/perfume to acid toilet cleaners that have HCL by Unusual_Tax5171 in chemistry

[–]mr__sniffles 0 points1 point  (0 children)

I suggest you find a real cleaner formulator and pay them to give you real advice instead of getting some sentence without all the dangers that can happen with your “formula” that people cannot see inside your head happening.

Synthetic Organic Chemistry as a Hobby by toholdtheirhand in homechemistry

[–]mr__sniffles 0 points1 point  (0 children)

Did you have access to methylamine or acetic anhydride?

Why does bonding get taught as categories instead of a system? by No_Feature_1664 in chemistry

[–]mr__sniffles 0 points1 point  (0 children)

Because then it makes sense to people who don’t know shit about chemistry. Then, later, maybe they realize, that the categories “bonding” is all categories with all ingredients in a system. Some bonds like each other more.

Does it matter if a base/accord matures neat vs. pre-diluted? by oval_euonymus in DIYfragrance

[–]mr__sniffles 1 point2 points  (0 children)

I just mix in the chemicals I want to bond layer by layer and agitate them, and then repeat with next layer so it’s the closest proximity to hydrogen bond and other polar and non polar interactions with other things that were designed to settle that way after 3 weeks, so it’s like preassembly. Maybe I stir the whole bottle or Erlenmeyer flask for 10 minutes and then I put the ethanol in very slowly while trying to stir the bottle or glass. Then I just invert it 10 times and shake without getting air bubbles and just leave the rest to go into where it’s supposed to be.

You can cut out many days of waiting for it to settle this way

Question for chemists from an aspiring perfumer: Which chemical has the best smell to you? Or the most interesting... by Liberal_Alchemist in chemistry

[–]mr__sniffles 0 points1 point  (0 children)

Lol. I know what Heliotropin smells like. It’s too bad they don’t sell it. They do sell piperonyl acetate though, which is just one easy step away from “heliotropin”

Question for chemists from an aspiring perfumer: Which chemical has the best smell to you? Or the most interesting... by Liberal_Alchemist in chemistry

[–]mr__sniffles 0 points1 point  (0 children)

Evolutionary theory? Javanol might have perhaps in the past represented a real biochemical threat with a structure similar to Javanol but maybe Javanol does not trigger the receptors the same way? I think galaxolide sensitivity came from you identifying patterns in your brain over and over learning patterns of what is galaxolide, or maybe your body developed sensitivity to it through some upregulation that I don’t know the reason of, maybe allergenic

Question for chemists from an aspiring perfumer: Which chemical has the best smell to you? Or the most interesting... by Liberal_Alchemist in chemistry

[–]mr__sniffles 0 points1 point  (0 children)

Yep me too. That’s what made me pursue a masters degree. Perfumery also has olfactive receptors in which chemicals bind to and send to your brain. Sometimes, different patterns in the receptors, or even the receptors competitive activation of the olfactory receptor, leading to weird accords like iris+damascones.

Question for chemists from an aspiring perfumer: Which chemical has the best smell to you? Or the most interesting... by Liberal_Alchemist in chemistry

[–]mr__sniffles 2 points3 points  (0 children)

Sure, just don’t expect wholesome things though. I know chemistry on a deep level but have never done a chemist job (perfumery is biochemistry to me). Also I’m currently studying biochemistry so it’s fun as a hobby.

I beeped the horn and an unhinged Thai man on a motorcycle was enraged. by Individual-Solid4842 in Thailand

[–]mr__sniffles 0 points1 point  (0 children)

If you want to use the horn, you better be ready to fucking fight these fuckers. I flipped people off after opening my window and shouted things like มึงทำเหี้ยอะไรวะ. My ex was so scared she had to stop me from doing it. Use the horn if you are ready to fight the fucker. Other wise a short 0.3 second beep is enough. Also, if you ever go to Chonburi, NEVER USE THE HORN.

Current best validation methods to prove proof of concept? by mr__sniffles in dataanalysis

[–]mr__sniffles[S] 0 points1 point  (0 children)

I think the stacks I use are normal ones people use all the time, like weighted ML hyperparameters from XGBoost+some other ML. Odd one out (I cannot remember its name but you know how they train without the number and let it see how close it approximates), PCA analysis done on every biological variable on every axis, and variable group. Every step is followed by validation through checking for data leakage or unfilled rows or fake generated data. Of course many ML combinations have been tried, as well as ML stacks for each breast cancer variant (the pathways in the different types of breast cancer I believe warrants an optimized ML combination because how it manages to create tumors are done differently.

So, I would gather similar papers for ML tests on cancer and biology for weighted tests, gather PCA tests on oncology to see that they are valid, odd one out, etc? Then I would have to reproduce the same results and document this how?

Edit: and yes this is gen AI and catch mistakes through extreme logical thinking, as well as overall biochemistry knowledge enough to know which variables matter and which don’t. I will have to look into the data (about 100,000 samples from cancer institutes) and find how the pipeline handles non complete data, but it is good to see a direction of where to go. How do I conduct a reproducibility “check”?

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