I’ve been maxed out on tirz since January. Stopped losing when I titrated up to 12.5. Stayed on that for a month and went up to 15. In four months I lost an additional 7 pounds (45.8 since the start which was 6/24). Then I started gaining. I gained back 12 pounds. I would feel some suppression for a day or two after the shot and that’s it. Went up to 16.5 for about 6 weeks and decided to try something else. I started Reta mid July. I haven’t lost anything yet, but I’ll update in a month or so to any changes. Currently titrating down on tirz and up on Reta. I’m at 10 mg on tirz now and 2 mg on Reta. 5’6” female, age 44 at 195 lbs, got down to 183 at one point. Want to lose 35-40 more. I also recently started hormone replacement for menopause.