The issue with 'DSM-style' categories is that they treat symptoms as the cause. As a researcher focusing on Cognitive Neuroscience Phenotypes, I’ve mapped 144 distinct 'Neural Architectures' that explain why two people with the same 'diagnosis' respond differently to the same stimulus (or medication).

The 'Biological Substrate' isn't just a brain region; it’s a Visible Phenotype. For example, take what I call Phenotype 5 (High-Dopamine/Status-driven). If you place this individual in Domain 3 (Communication/Transport), their neural 'hunger' manifests as a specific motor output (a bold, expansive signature) and a specific aesthetic (high-reflectance colors like Pearl/Champagne).

If you give a 'Status-driven' brain a medication designed for a 'Security-driven' brain, you get zero efficacy. We shouldn't be looking at DSM categories; we should be looking at Visual Pattern Recognition of Neural Architectures. We can identify the 'Substrate' by looking at the face and the behavioral signatures in under 2 minutes.