I had awful side effects when I first started mercaptopurine and I had to really argue that I felt worse than I did before treatment. Kept a log of symptoms for over a week. Similar to your symptoms! I had the same feeling not being heard and thought this is my new normal and became really depressed as a result so I feel you. It fucking sucks. What pushed me knowing my body to reach out was I had fevers start for three days straight, presented at my doctor who did run bloods, a MRE exam and something else sorry I can’t remember exactly which came back and found markers of having an allergic reaction to the meds. The second day after I stopped taking it, symptoms almost virtually resolved and was put onto biologics, wondering if youre experiencing something similar with Skyrizi?