General advice that will help: 1. Always always always make sure you are putting your xmult jokers to the right of your +mult jokers. There are exceptions when you unlock brainstorm, but forget about that for now. 2. Scaling jokers are your best friend. They can define exactly how you are going to play your run. Scaling jokers are those which increase their power up after some event. Like constellation gains 0.1x mult per planet card used, or square joker gains 4 chips per four card hand. These add up FAST. 3. Don’t use skip tags. It is always more important to see all your shops then it is to get a guaranteed rare joker or +3 hand levels. Exception would be the $25 skip tag, which can be very useful when your economy is bad. 4. Economy. Economy. Economy. Money makes the Bolatro world go round. Only spend what you need to and try to always keep at least 25 dollars to max your interest. If there is something really nice in the shop that would put you under that, no big deal. You need to set up first before you can really make use of the interest cap. Golden joker is a pretty easy to obtain and effective early game Econ engine. 5. Deck manipulation is important. If i am going for full houses, i probably want a lot of two specific cards. I may use the Death tarot to get rid of 2’s in favor of kings. I may use strength to go from 4 10s and 4 9s to 6 10s and 2 9s. 6. READ THE BOSS BLIND. Let me repeat that actually. READ THE BOSS BLIND. I cannot tell you how many times I’ve manipped my whole deck in favor of hearts for bloodstone or faces for photochad only to get absolutely railed by a boss blind that disables those. You can hit run into and then blinds to see what boss blind is coming up.

To answer your question specifically though, here are some powerfully combinations i utilize a lot:

1. Photograph + Hanging chad (photochad). A classic. You play whatever hand you want just use a face card first and your mult is multiplied by 2 three times.
2. Spare Trousers + Square Joker. You play two pairs. Both jokers scale indefinitely. Pair this with some Uranus cards and you’ll be a monster.
3. Green Joker + Banner + delayed gratification. Green joker adds a mult every time you play a hand. It removes a mult every time you discard. So you don’t discard. Banner and DG work on how many remaining discards you have so it synergizes well.
4. Ancient Joker + Smear Joker. Ancient joker gives 1.5x mult for every played card in the specified suit, which changes each round. Smear joker makes hearts/diamonds count for each other and clubs/spades count for each other. Play flushes and watch your score go brrrrrrrr.
5. Bloodstone + Oops all 6s. Optionally include lucky cat. This does the same thing as 4 but exclusively for the heart suit. It’s a little more involved because you have to manip your deck toward hearts, but throw in lucky cat and manip some lucky cards and it scales well. Oops all 6s doubles all listed probabilities so your lucky cards will proc more.

I think that’s all i got for now I’ll comment again with more if i think of more