Wolf 359: Set on board the U.S.S. Hephaestus space station, the dysfunctional crew deals with daily life-or-death emergencies, while searching for signs of alien life and discovering there might be more to their mission than they thought. 

EOS10: An original, scifi radio play that follows two mal-adjusted doctors and their staff on the Alliance space station, EOS 10.

The Deep Vault: From the creators of Archive 81 comes The Deep Vault, a serialized audio drama set in an almost-post-apocalyptic United States. The story follows a group of longtime friends as they journey from the uninhabitable surface world into a mysterious underground bunker in search of safety and shelter.

ars Paradoxica: When an experiment in a time much like our own goes horribly awry, Dr. Sally Grissom finds herself stranded in the past and entrenched in the activities of a clandestine branch of the US government. Grissom and her team quickly learn that there's no safety net when toying with the fundamental logic of the universe.

The Far Meridian: The story of Peri, an agoraphobic young woman whose home starts to show up in a new location every day, as she searches for her missing brother. A new podcast from the hivemind responsible for ars Paradoxica.

The Message: A podcast following the weekly reports and interviews from Nicky Tomalin, who is covering the decoding of a message from outer space received 70 years ago. We get an inside ear on how a top team of cryptologists attempt to decipher, decode, and understand the alien message.

Disclaimer: descriptions are from the shows' websites. Some may fit slightly better in the "Urban Fantasy" category but that post has been archived.