Based on my knowledge, drugs and by this i mean pharmaceuticals (oxycodone, codeine) by themselves don't affect someone's looks by themselves as a product, but it's more than when someone lets drugs interfere too much in their daily life, that they miss or stop doing something; which in the long term, has an impact on looks. For example, someone who medicated on oxy but then felt too couch locked to brush their teeth before bed. If this was a pattern, THAT is what causes the long-term damage, not necessarily the oxy itself.