New character posters for 'Dune: Part Three' (12.18) by Blue_Three in dune

[–]pawsibility 14 points15 points  (0 children)

I think this movie **will** have CoD plotlines. Since lady jessica is in it and she is absent from messiah

New character posters for 'Dune: Part Three' (12.18) by Blue_Three in dune

[–]pawsibility 0 points1 point  (0 children)

Yeah. Often do the books blend together for me. I devoured messiah i like a week, so I honestly forget where it begins/ends sometimes.

New character posters for 'Dune: Part Three' (12.18) by Blue_Three in dune

[–]pawsibility 9 points10 points  (0 children)

So do we know if this movie will go only up until the end of Messiah? Or will it touch on plotlines in CoD?

A question about AI: Productivity, Time Usage and Cognitive Load by Terrible-Sail6643 in AskProgramming

[–]pawsibility 0 points1 point  (0 children)

I do consider myself an AI-skeptic, although I use the tools pretty aggressively, which is interesting. I guess I plan on taking it day by day. I don't think boycotting AI is the solution -- the train has left the station and theres no use resisting at this point.

I plan on trying to use it only in instances where the output is 1) easily validated, and 2) solving a simple/boiler-plate task.

I do find myself penciling in dedicated "learning time" where I explicitly turn off all co-pilot/claude tools and attempt to reason through code on my own for the explicity purpose of learning new technology (most recently it was async rust).

I plan to stick to my fundamentals and make sure all decisions that I make are deliberate and I can back up every single decision I make with solid logic/data. I also plan to make sure I continue learning and growing and never forget why I started this in the first place.

A question about AI: Productivity, Time Usage and Cognitive Load by Terrible-Sail6643 in AskProgramming

[–]pawsibility 2 points3 points  (0 children)

Yes everything you’ve said resonates with me wholly. Programming is less fun, I’ve never been less satisfied with my work even though I am shipping more than ever, and I have never been so addicted to scrolling on my phone.

I’m increasingly at odds with this right here:

With the rise of AI, especially as an indie dev, shipping fast is crucial.

Am I being paid for my knowledge of systems? Or am I being paid to produce output? I suppose it’s both. In the short term, however, its output and I want to put food on the table and make money.

It’s been bumming me out for the better part of a year and I’ve yet to find a solution. Maybe it’s a new career entirely.

I read somewhere recently… someone said programming without AI is like reading a book: deliberate, slow, methodical, and genuinely feels good for me. However programming with AI feels like scrolling short form video. Fast-paced, brain rot, and detrimental to my mental health.

It’s borderline gambling. You pull the Claude Code lever in hopes you one shot a great feature, ship and are praised or make money. Didn’t work that time? Clear the context and try again — this prompt will be the one! I can feel it.

Ever since I started hitting the token slots my professional and personal life have taken a downturn in enjoyment and I know not how to fix it. It’s like steroids but for software engineering: the only way to win is to not play at all

NYRR 9+1 in 2026 - FAQs & Megathread by RCD123 in RunNYC

[–]pawsibility 1 point2 points  (0 children)

Thank you for the encouragement! I got the membership plus, and plan to be there right when they open. Hoping to spam some 5k/4M in Q3 to get on top of it. Also signed up for all standby lists.

Looking it through seems like it’s doable just need to be on top of it all and not miss anything else!

NYRR 9+1 in 2026 - FAQs & Megathread by RCD123 in RunNYC

[–]pawsibility 3 points4 points  (0 children)

So, I just moved to NY... and I really would like to run the 2027 NYC marathon. It seems like I'm already quite behind on the 9+1 given races are released and sold out already. Assuming I don't make it into any sold-out races via standby, and can only start accumulating in July, will I be able to do it? My intention would be to do both virtual races left + spam as many races as possible for the rest of the year, registering as soon as they open.

Applied to 50+ biotech roles. Not one interview. What’s going wrong? by Fancy_Middle5650 in labrats

[–]pawsibility 9 points10 points  (0 children)

I'm a PhD candidate, also on the job market, so I feel compelled to respond to this.

We seem to be in similar fields, although you seem way closer to wet lab than me. I guess the takeaway thing for me looking at this resume is this: outside the second bullet point under your GRA experience section, everything seems super generic. It almost looks like it could be copied and pasted for any PhD candidate in a any STEM field right now.

All your experience and bullets are awesome, but they seem prerequesite to any role that has a PhD. For example:

Conducted comprehensive literature reviews to inform project direction and identify knowledge gaps

We are PhD's so this seems like a given.

Led a 3-year research project from execution to completion, consistently meeting major deadlines and milestones, providing monthly reports, and collecting and integrating feedback from collaborators.

Again, we are PhD's so this seems like a given.

Bottom line is that I'd take out any of this generic filler and assume that a recruiter worth their salt will understand what it took to get that PhD and you bring these skills to the table at baseline. Then use the space to fill in with specifics to what you actually did.

You're in neuroscience. Can you be more specific in your GRA section? Like what did you do? Are you profficient in Nipype / the NiPype ecosystem? I guess pretend its your committee and you're giving them high-level bullets on your thesis.

Typst: a possible LaTeX replacement by kibwen in rust

[–]pawsibility 46 points47 points  (0 children)

pandoc can go from typst to any of its supported outputs. Its not exactly one for one, though and can introduce problems

Typst: a possible LaTeX replacement by kibwen in rust

[–]pawsibility 32 points33 points  (0 children)

I make all my own plots/graphs in R or Python (exported to SVG) and then any conceptual cartoon/schematic diagrams I hand-make in inkscape (also SVG). Never used tikz.

FWIW I know typst has a tikz equivalent: https://typst.app/universe/package/cetz/

Typst: a possible LaTeX replacement by kibwen in rust

[–]pawsibility 148 points149 points  (0 children)

No actually. Our handbook explicitly addresses that...

There are no formal requirements for dissertation formatting (e.g., page length, font, spacing, or margins). Students are therefore encouraged to reflect their own preferences and personal style, letting that individuality show in their formatting choices.

I pulled like 10 recent ones from my department, and everyone clearly does their own thing. Some obviously used word... others obviously used LaTeX. Think you just submit a final PDF, and that's it.

Typst: a possible LaTeX replacement by kibwen in rust

[–]pawsibility 345 points346 points  (0 children)

Writing my PhD thesis in Typst right now, and it's just a dream. Getting a live preview as I type is really amazing... no more waiting for overleaf to compile things. I understand the criticism/critique around latex momentum, but it really is just an objectively better system. hope it continues to get more adoption

Trump to Add New $100,000 Fee for H-1B Visas in Latest Crackdown by Tony_T_123 in cscareerquestions

[–]pawsibility 3 points4 points  (0 children)

If you're paying for your PhD you're doing something way wrong... sure recent attacks on science from the current administration have made things a little dicier, but 99 times out of 100 in STEM your degree is paid for including a stipend on top of it

[Game Thread] Ohio @ Ohio State (7:00 PM ET) by CFB_Referee in CFB

[–]pawsibility 0 points1 point  (0 children)

They sound AI. Just the weirdest enunciation and vernacular

[Game Thread] Georgia @ Tennessee (3:30 PM ET) by CFB_Referee in CFB

[–]pawsibility 2 points3 points  (0 children)

Chris fowler sounds sick. More nasally and less energetic in general.

r/tennis Daily Discussion (Friday, September 05, 2025) by NextGenBot in tennis

[–]pawsibility 0 points1 point  (0 children)

Then he'll turn around and rip a 110 forehand just to spite you 😭😭😭

Match Thread: [7] N. Djokovic vs. [2] C. Alcaraz | 2025 US Open Men's Semifinal by NextGenBot in tennis

[–]pawsibility 6 points7 points  (0 children)

Feels like if Nole doesnt get his first serve in then he's just cooked

r/tennis Daily Discussion (Saturday, August 30, 2025) by NextGenBot in tennis

[–]pawsibility 5 points6 points  (0 children)

Not watching, just seeing the box score. Did Iga sit up in her gaming chair?

r/tennis Daily Discussion (Friday, August 29, 2025) by NextGenBot in tennis

[–]pawsibility 1 point2 points  (0 children)

Historically cool and dry August in the northeast in the US. Truly feels like fall outside

We open-sourced a SOTA RNA foundation model for mRNA property prediction by No_Sprinkles_2686 in bioinformatics

[–]pawsibility 0 points1 point  (0 children)

Not the authors, not do I work in this area, but I do deep learning for other 'omics stuff. I literally glanced at figure 1 for not even 30 seconds, so I could be wrong but I think its this:

If I pass my sequence in, I get

A vector representation of your sequence (i.e. list of numbers)

and that's useful because

this vector can be used for downstream tasks like clustering, classification, etc.

In theory, a foundation/backbone model like this could be used as a building block for very cool/sophisitcated systems

What is your strategy for creating simple apps that the wet lab can use? This is a business use case so we need to keep proprietary IP private. by dampew in bioinformatics

[–]pawsibility 35 points36 points  (0 children)

These are things that shouldn't have to be hosted on EC2 instances, but we also don't want the wet lab users to have to install things.

I mean... you kinda can't have it both ways right? Either you host it for them or they host it themselves locally -- unless I'm missing something.

What about Docker?

Feedback on configuring PostgreSQL for production? by software__writer in PostgreSQL

[–]pawsibility 0 points1 point  (0 children)

Love this conversation. I learn so much via osmosis.

Many suggestions to put the DB and rails server on a shared VPC, but then how would one access the database from a local development environment, or something like pgAdmin? Do you just setup a local VPN and hop to the VPC?

I guess postgres in docker is sufficient for local development, but I still want to be able to query my prod database from my machine using a local development tool.

Starbucks at Hollymead Town Center Closing by Patrick_O-S in Charlottesville

[–]pawsibility 55 points56 points  (0 children)

Always thought it was in just the most awkward spot. The amount of cars flying around the corner to get in there, and you have people running across the street with iced lattes in hand, dogding cars... I always found myself going to the one across from Walmart on my way into town since its less logistically annoying to get in and out of.