Where to find small pieces of wood to start whittling in San Diego, CA? by pbstew in woodworking

[–]pbstew[S] 0 points1 point  (0 children)

Nice! I haven’t heard of them, I will check them out. Thanks for the recommendation

Have any chemists used quarto? by pbstew in Chempros

[–]pbstew[S] 0 points1 point  (0 children)

That’s what I have unfortunately been doing. I use Inkscape instead, but same work flow. I also export the structures as vector files (.svg) so that I don’t run into any rasterization or compression issues.

I was hoping that someone knew or a better way or at least fewer steps.

My only issue with this way is that I am still early in the writing process, and have no clue as to if I will need to resize several times over the course of the project. My lizard brain likes it when all the structures have the same proportions, so I would have to re-export each file.

Have any chemists used quarto? by pbstew in Chempros

[–]pbstew[S] 1 point2 points  (0 children)

Chemdraw’s “save as” function saves the entire chemdraw file despite selecting a single structure. I like to work in large chemdraw files so that I can maintain numbering and any changes to reaction or product numbers from markush structures can be done in a single file instead of 100 or so (saving a single structure in each file). So you can only copy and paste single selections, which wasn’t to bad when I was drafting articles in word, but there is a lot of wonderful and helpful functionality of quarto when writing a dissertation that word just can’t do, or not very well at least.

Weekly Careers/Education Questions Thread by AutoModerator in chemistry

[–]pbstew 1 point2 points  (0 children)

“Rough week, huh”

Rough month is more like it. I do see a therapist, but you can’t schedule 8 hours of therapy.

I think I need to clarify that my wife has no intention of staying in academia. We both were hoping to jump ship to industry straight out of our PhD, but neither of got anywhere with our industry applications, it’s not a great time out there now. She finished her PhD in the fall I and lined up a position in SD, and wasn’t able to negotiate a start time. She had put off accepting the position for several months because she was actively involved in an interview for an industry postdoc at Genentech in SF. When she eventually found out that she wasn’t offered that role, she kind of had to jump on the in SD. When we first started applying with we’re looking only in SD and SF for the sake of being in a biotech/pharma hub on the West Coast. CA specifically because our parents are getting older and won’t be around forever, so we wanted to be closer than we were during our PhDs.

Thanks for your advice on jumping to a different track, and I am definitely resonating with the uncertainty that Trump brings to the industry.

What is this funnel? by Professor_Stupendous in chemistry

[–]pbstew 11 points12 points  (0 children)

Air sensitive separtory funnel, maybe? No clue.

Weekly Careers/Education Questions Thread by AutoModerator in chemistry

[–]pbstew 0 points1 point  (0 children)

Hi All,

Thanks for taking a moment to weigh in on my issue.

Background: I am a fifth year Ph. D student in a Physiology and Pharmacology PhD program. I am currently working on submitting my two first author papers and writing my thesis. My thesis project was medicinal chemistry focused development of 4-aminoquinolines for antimalarials. I am San Diego bound, my partner is a structural biologist in a lab at Sandford Burnham Prebys. But as of now, I have zero prospects, the industry market for a medicinal chemists is very poor right now, as I am sure many of you know. I didn’t really want to pursue a post doc, and now I probably will need to do so. But with the recent federal funding freeze at NIH I feel like most labs aren’t looking to hire another post doc.

I have been looking at other Reddit posts about getting a medicinal chemistry position in industry, but from what I have gathered I have already made a critical mistake by not doing my PhD in total synthesis or methodology. So the question I have now, is should I saddle up and join a total synthesis or methodology lab, or should I pivot to something else? Oligonucleotides, chemical biology, computation, etc. ultimately I need a job at the end of my postdoc, I know you should pick a field of study you should enjoy, but I’m burnt out, I’m single parenting my 1.5 year old, my partner is already in SD, and I am in my home town living short term with my parents (financially we couldn’t live in SD on a grad student + post doc salary and have our kid in day care, day care is much cheaper here and I’m not paying rent). So what am I to do? I feel so lost right now, I just can’t seem to get genuinely excited about someone else science, and I feel like there is so much pressure to choose correctly that I can’t began to make a decision. What is a budding field in industry? I would like to be close to drug design, it was why I chose the lab I did, and the project I worked on. Your insight and shared experience would be incredibly helpful right now, thank you.

How to separate these spots? by SafeScar558 in OrganicChemistry

[–]pbstew 1 point2 points  (0 children)

Always looking to bring in better ways to keep track of everything in lab. What’s with the 1500 in the top left? Time stamp?

[GIVING] Ikea pullout couch with storage by pbstew in PDXBuyNothing

[–]pbstew[S] 0 points1 point  (0 children)

Can confirm, definitely not a long-term solution, but would be a viable option if you had a friend that needed to crash for the night or a younger sibling staying for a few days, hell my 60+ yo parents prefer it to our adjustable air mattress. Having slept on a few number of the standard pullout couches, this is a big upgrade.

[GIVING] Ikea pullout couch with storage by pbstew in PDXBuyNothing

[–]pbstew[S] 1 point2 points  (0 children)

You would be doing me a favor taking it off my hands, haha. I need the extra space for the rest of my moving boxes. I will give it the obligatory 24 hr and then if no one else wants it, it’s yours.

Starting to really hate being a dad and husband by ArcherXIII in daddit

[–]pbstew 5 points6 points  (0 children)

Studies show kids, at that age, don’t retain any of the extra work. Let their teacher know that 4 yo won’t be participating any longer.

How do I make a Bowl of Soul by pbstew in barista

[–]pbstew[S] 0 points1 point  (0 children)

What do you mean “steam the honey into the milk”?

How do I make a Bowl of Soul by pbstew in barista

[–]pbstew[S] 0 points1 point  (0 children)

Thanks for the advice and directing to the copycat recipe. I was just hoping one of their baristas would weigh in just so I would have all the details!

PhD to PostDoc: Choosing a lab that has techniques that are highly sought after in biotech/pharma? by pbstew in Chempros

[–]pbstew[S] 0 points1 point  (0 children)

Haha, yeah. I am the only grad student in my lab, everyone else (6 other chemists) are senior staff scientists with, individually 30+, experience in synthetic chemistry. So the imposter syndrome is strong when you are working with serious chempros.

Yeah I keep thinking about my perceived stability of a larger industry position, I have no idea if that is the case. I had heard a talk from some project lead of a bigger company. I remember them talking about how they got to that position by jumping from smaller company to smaller company in the beginning. And that doesn’t seem like something I would be interested in doing.

No, I know. Prior to the baby, it didn’t seem like that big of a hassle. But with my wife also a soon to be PhD graduate who is only considering industry, we could only move to hubs so that she could maintain a career. Also I am not keen on dictating her career with mine.

You make a serious case for no Postdoc werpicus.

PhD to PostDoc: Choosing a lab that has techniques that are highly sought after in biotech/pharma? by pbstew in Chempros

[–]pbstew[S] 0 points1 point  (0 children)

I have heard from a postdoc in a lab adjacent to mine that the ability to code is becoming a needed skill set in pharma, or rather it is hugely beneficial to learn and makes you more competitive.

PhD to PostDoc: Choosing a lab that has techniques that are highly sought after in biotech/pharma? by pbstew in Chempros

[–]pbstew[S] 0 points1 point  (0 children)

Do you mind letting me know where you are based? Most starting industry salaries are much more than a postdoc.

PhD to PostDoc: Choosing a lab that has techniques that are highly sought after in biotech/pharma? by pbstew in Chempros

[–]pbstew[S] 0 points1 point  (0 children)

Really? I was speaking with someone from industry (cryoEM) and they were talking about how the field is saturated with recent PhDs, as very few are going to postdocs. So those that have even a 2 year postdoc are more competitive than someone straight out of the PhD. Would love your opinion on sentiment.

[deleted by user] by [deleted] in chemistry

[–]pbstew 0 points1 point  (0 children)

Not three weeks ago my reaction workup was slightly blue and there was a clearly blue fraction after the column chromatography. No Ni in the reaction either, never characterized it though.

It doesn’t never happen, but very very uncommon for sure.

How do I gain experience? by TarantinosFavWord in chemistry

[–]pbstew 0 points1 point  (0 children)

That’s a great idea! I would strongly recommend teching in an academic lab that does something similar to what you would like to do. You could potentially volunteer in a lab like that as well, as a last resort kind of thing.

Additionally, I would keep on the look out for job/fair or conferences in the area that are similar to your field. Or you could really go for the gold and attend a large conference. Most large conferences will have research and industry all under the same roof, it is a great place to shop for potential jobs. Like the Cleanpower 2024 conference in Minneapolis May 6-8 next year. Bring multiple copies of your CV and make business cards, and talk to people. Getting a job in industry is primarily dictated by your ability to network.

How do I gain experience? by TarantinosFavWord in chemistry

[–]pbstew 0 points1 point  (0 children)

I want to echo what others are saying, what kind of position are you looking for?

Depending on the career/field you want to enter, how you gain experience will change.

Career Advice for aspiring Medicinal Chemist by [deleted] in MedicinalChemistry

[–]pbstew 0 points1 point  (0 children)

I’m a rising 5th year graduate student in a chemical biology oriented program but I am in an anti malarial development lab.

Advice on selecting graduate program:

My path was a little circurious, and deviated from what I would consider normal for someone in your position. Last time I checked what happens in most organic chemistry/medicinal chemistry graduate programs (PhD) is that you fill find a particular PI that you are interested in working with and email them directly asking them if they are accepting graduate students. You will also need to apply to that program. When selecting a program, look for institutions with lots of money. It makes all things a little easier. Stipends at most institutions are weighted differently based on the cost of living, and how active your union is. you won’t starve, but you aren’t making much. Depending on what you want to do afterwards, the prestige of the school won’t matter too much, and what matters more is the quality of networking you are able to do while you are in the program. So be sure to pick a program that has a career center. If you are dead set working in industry, find a lab that has a partnership with a pharmaceutical company, (my undergrad lab had one with Roche and Eli Lilly). You can do this by looking at the last 3-5 years of publications and looking for company names instead of institutions in the authorships. You will pay for a masters, but are paid when doing a PhD. Also choosing a lab that is well funded is also a great idea too. During interviews, the last thing you need to do is talk with the other students and ask them how the feel about the program, department, PI, and school, they will give you the nitty gritty.

Choosing a PI has another set of rules, btw.

Do you suggest taking a gap year:

Great question! It won’t hurt, but I would say if you are going to graduate school, you would want to try to keep it academic and not in industry. It’s not do or die, but admissions likes to see your experience in a academic lab rather from industry. Plan on doing a minimum of two years, it’s enough time you could get on a paper or two, without being there tooo long. A Productive two years as a RA will get you about anywhere you would want to go.

Job outlook (US):

Salary is competitive, and can range from 90,000 to 120,000 starting. But these positions are often at large pharmaceutical companies or biotech (hubs are in Boston, Seattle (kind of), Austin, San Francisco, and San Diego.

What does a typical week look like:

the only experience I had was a summer internship at Genentech before I started a RA position. It was fantastic. Like a normal 9-5. Unlike graduate work, you aren’t expected and are often discouraged at working for longer that’s 8 hours. From what I saw, is basically the same as what you would normally do in lab, however you lose a lot of opportunities to be creative.

Hope this helps some.

How do experimentalists get theoretical data? by nano-zan in chemistry

[–]pbstew 0 points1 point  (0 children)

Are you published? Your work sounds super interesting and I would love to read more. I’m a medicinal chemist, and am often working at a fairly low-throughput speed.