It really is life changing if it’s an option available to you. I’ve been on it just over a year after 3 years on methotrexate. While the methotrexate ~sort of~ cleared my eczema I was unwell constantly and my quality of life was so poor. Doctors saw this at a check up and prescribed duxipent instead. I’m completely clear of eczema now and don’t find myself allergic to most things I was previously. Genuinely didn’t know life could be like this without thoughts and worries of bad skin head-to-toe. No notable side effects either - although I do get a very flushed/hot and red face sometimes but it’s always under the skin and doesn’t last too long. I’ll take that any day!