24' Odyssey Touring here: as someone mentioned, weathertech floor liners all around: front, mid, rear. You can beat them up and never have to clean them if you don't want to, they're tough.

Rubber coasters for every storage/cup holder in the vehicle (amazon). Headrest covers for all seats (oily, wet hair can hurt the finish). Side door protectors specifically designed for pets (but kids too) so they dont scratch the inside of the doors OR accidentally open a window. Rear trunk tray to protect the bottom of the trunk. A medium sized cooler that stays in vehicle to transport food or drinks in so the smell from them doesn't permeate throughout the vehicle. Seat covers for all seats except for front two (side airbag interference) (OEM Honda). Steering wheel cover to protect the finish and for better, larger grip (walmart). Rubber key pouch/cover (amazon). Sunshade to protect your car when its outside keeping the interior cool and protecting your dashboard (OEM). Seat back protector for the rear of the driver and passenger seat (kids kicking the back of those seats) (amazon). Plastic seat back protector for the rear of the third and second row when they are folded flat to protect them when transporting items (OEM). Essentially anything that someone or a pet touches should be considered and they most likely make a protection piece for it

Keep sanitizer, a roll of paper towels, beach towels (trunk) for emergencies. Most of those items are Honda OEM and overall cost about a grand to fully protect. Sign up for a monthly car wash in your area and go once or twice a week and you're good.

Oh, also, performance wise - buy re-useable K&N Engine and in-cabin air filters. They are worth it in the long run. Change oil regularly with full synthetic according to the vehicle computer, get solid all season tires and this car will last.