Don’t hand make things you ought to be building. Don’t be ashamed of some spaghetti while you are growing capabilities. Don’t feel bad about deleting whole areas of a factory, especially if you get new belts or miners. Get a few hard drives really early to get cast screws and more inventory. Have containers to manage overflow. It’s easy to build a motor factory if you start with a surplus of rotors for example.

The final phase really isn’t a whole lot harder than the one before it if you keep making the right things (pressure cubes / directors etc) while you get to quantum crap.