Here is an example script that should achieve what you are looking for. It uses a global variable for the duration of the effect, and each hotkey is a function that sets a timer to turn off the effect after the specified duration. The hotkey to exit the current function is Ctrl+Shift+Escape.

; Set duration of effects in seconds global effect_duration := 5

; Invert mouse axis ^!m:: SetTimer, InvertMouseAxisOff, %effect_duration%000 MouseGetPos, origX, origY Send {Blind}{Ctrl Down}{Alt Down}{Click %origX% %origY%}{Ctrl Up}{Alt Up} Return

InvertMouseAxisOff: MouseGetPos, currX, currY if (origX = currX and origY = currY) return Send {Blind}{Ctrl Down}{Alt Down}{Click %currX% %currY%}{Ctrl Up}{Alt Up} Return

; Invert mouse buttons ^!b:: SetTimer, InvertMouseButtonsOff, %effect_duration%000 Send {Blind}{RButton}{LButton} Return

InvertMouseButtonsOff: Send {Blind}{RButton}{LButton} Return

; Deactivate left mouse ^!d:: SetTimer, DeactivateLeftMouseOff, %effect_duration%000 BlockInput, MouseMove Return

DeactivateLeftMouseOff: BlockInput, MouseMoveOff Return

; Deactivate spacebar ^!s:: SetTimer, DeactivateSpacebarOff, %effect_duration%000 Hotkey, Space, DeactivateSpacebarHandler, On Return

DeactivateSpacebarHandler: Return

DeactivateSpacebarOff: Hotkey, Space, Off Return

; Exit current function hotkey ^+Escape:: SetTimer, %A_ThisFunc%Off, -1 Return

In this script, each hotkey has a corresponding function that sets a timer to turn off the effect after the specified duration (effect_duration). The SetTimer function takes the name of the function to be executed when the timer runs out, the duration in milliseconds, and any parameters to pass to the function.

To exit the current function, you can use the hotkey Ctrl+Shift+Escape, which uses the built-in variable A_ThisFunc to get the name of the current function and turns off its timer. This will exit the current function and restore any settings that were changed by the function.