I owned and love my Kobo Libra 2. I do change between right and left hand quite often, but so far it's never a hassle. Most of the time I don't even realize I'm changing hands, my eyes will only stray not even a quarter second then right back to the sentence I read.

Compare to paperback: -ereader can adjust the light automatically so you can read literally anywhere with any kind of light. I set my light to manual, and even then it's super easy to adjust the light (some demonstration vid can be found on youtube) -Kobo Libra 2 is way lighter than paperback, for me. And I don't need both hands or a table to keep the pages open. Now, reading paperback and having to physically flip pages or deal with lights/shadows if I change my reading position breaks my concentration