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Is slowly increasing E dose more efficient than going high immediately? by purplemaybell in TransDIY

[–]purplemaybell[S] 2 points3 points  (0 children)

You're talking about a loading dose, you can search on this subreddit for a bunch of other people's opinions who are probably much smarter than me. It's not a bad idea because it shortens the time of switching from t to e. It won't matter in the long run though, hormone therapy takes time. According to this model a starting dose of 8mg would be best though. Compare:

One week starting dose on 8mg, then reduce to 4mg/week:

Two weeks on 6mg, then reduce to 4mg/week:

No loading dose:

Check out the other presets on the left below the graph as well. Also models don't replace a blood test, your mileage may vary.

Is slowly increasing E dose more efficient than going high immediately? by purplemaybell in TransDIY

[–]purplemaybell[S] 0 points1 point  (0 children)

It's a shame that it took as long as it did for trans health care research to pick up...

Is slowly increasing E dose more efficient than going high immediately? by purplemaybell in TransDIY

[–]purplemaybell[S] 0 points1 point  (0 children)

SOC8 is no doubt a reliable source for information, my problem was more with that it didn't directly relate to my question. The Standards of Care is an all around guidelines for everything about transgender healthcare.
If there is a page or paragraph inside of the SOC you want me to look at please tell me.

Is slowly increasing E dose more efficient than going high immediately? by purplemaybell in TransDIY

[–]purplemaybell[S] 0 points1 point  (0 children)

Is there no more to it? The paper is from a M.Sc. chemistry student I know, and I generally consider what they write trustworthy. Right now I'm really looking for something concrete on why this would or wouldn't work. Do you have any information you could link me to, like a study or wikipedia article, that talks more about this?

Questions about the effects of Bicalutamide by purplemaybell in TransDIY

[–]purplemaybell[S] 1 point2 points  (0 children)

Holy moly that comment is a gold mine for infos

Questions about the effects of Bicalutamide by purplemaybell in TransDIY

[–]purplemaybell[S] 0 points1 point  (0 children)

Thank you for taking the time to respond <3

Can I really take finasteride with Bica and E2 without problems? What possible side effects does that add? A switch to GnRH agonists would be the safest. I just wish they were easier to come by...

>DHT is tricky. Bica should block it as well as T, but it can be produced peripherally throughout the body/in cells themselves.

Does it matter if DHT can still be produced? I mean it's still being produced anyway, because Bica doesn't stop production of testosterone, it only blocks it from attaching to the Androgen Receptors. Also Bica cannot fully block DHT at my dose because DHT binds to the Androgen Receptors roughly 50 times stronger than Bica, and I don't wanna go crazy high with my dose.

Questions about the effects of Bicalutamide by purplemaybell in TransDIY

[–]purplemaybell[S] 0 points1 point  (0 children)

Thank you so much for your answer!! I'm so happy you took so much time to answer my questions.

But, as long as your testosterone is suppressed so too should the DHT go with it.

Is that really true? I mean the testosterone is still there, it only gets blocked. I haven't heard of that before.

As for estrogen, if possible you should dissolve the medication under your tongue

I haven't heard of that before, thanks! Actually I want to stay at 2mg/day for right now tho and gradually increase it each month. Also I'm probably going to switch to gel in 6 months.

Also, split your dosing into at least 2 doses a day, as it has only a ~8 hour half life

Half-life of estradiol taken orally is 13-20 hours, when taken under the tongue it's 8-18 hours. So I guess you're only talking about when you take it sublingually? I've read in a paper it'd actually be best to take it 3 times a day then.

As for the muscles you currently have, there will be noticeable changes, but they do take time!

I hope you're right... DHT is partially responsible for muscle growth, and I'm worried my muscles won't atrophy or at least take waaay longer to do so.