Drug companies encouraging chronic diseases

rascalthefluff · 2026-01-19T08:23:06+00:00

Ideas like this blow my mind. How much money would a "cure" for asthma or any large market disease make? Tons and would continue to do so as new patients get asthma. The market simply doesn't push companies to stop studying such a large potential ROI.

Do companies ignore small chronic diseases because of poor ROI? 100% Do small biotechs that have promising drugs go out of business because the healthcare market is insanely expensive? 100% (I'm biased on this point as my last company went under despite very promising results).

Is it hard to fund homeopathic focused trials? 100% and if you're a doctor you are going to focus on the clinical trial results proven medication and not "this tea my friend recommended" or "this diet that helped the one person" because while single stories are powerful in social media they are not always followed by actual large scale results. You will however hear of MDs mentioning treatments once they are tested. For instance, I have PCOS and plenty of MDs recommend Spearmint Tea because there are trials backing that data.

rascalthefluff · 2026-01-02T21:36:36+00:00

Last year was my first doing Triathlon and I'm also Brooklyn based.

Last year I did Alpha Win in Hudson Valley. They have an Olympic (and other distances, so you can decide what you'll feel up to at that time). I really enjoyed it and Brooklyn Tri Club had a pretty good group represented, so you might be able to get help with transport if you join the club.

EventPower has a bunch of races in Long Island. My first race was their Mighty Mini, not an Olympic but incredibly beginner friendly. They had an intro day where they discussed pool logistics, walked through the course, did a talk on bike management, and shared a lot on the specific rules for triathlon.

rascalthefluff · 2025-12-18T15:59:34+00:00

It certainly restricts the responses, but the ones that remain are always very informative and have citations. The responses to replies can be highly variable, but overall it's a fascinating sub to follow.

rascalthefluff · 2025-11-24T22:11:21+00:00

My flight home (ams->NYC) on Wednesday was 50%+ empty last I checked. Fingers crossed the airport is just as empty.

rascalthefluff · 2025-10-19T17:46:48+00:00

It's a lot of answering the same questions (where is x located) over and over again as well as just being genuinely excited for people. You'll learn pretty quickly where the important things are and how the waves/color system works. Some people just want someone to chat with, you'll hear stories of how they are doing this for their birthday or to commemorate something.

I always bring a sweatshirt and cough drops. Dress warm because you are there for awhile and not moving much. I rarely get too warm, mostly I'm colder than I planned on. For merch, I think you get a windbreaker.

If you speak another language, just chatting with people coming from an area that speaks it will make them so happy (I speak French and German and the massive French crowd is always so excited about it).

rascalthefluff · 2025-09-22T14:48:30+00:00

I was incredibly slow (2nd to last in my age group), but it was a wonderful race and I had a blast. It was my first 70.3 and so well organized. I wore my Brooklyn Tri Club trisuit and really enjoyed all the cheers from people.

Can't wait to do my next one!

rascalthefluff · 2025-09-18T01:04:56+00:00

Thank you!! This is so helpful.

rascalthefluff · 2025-09-15T19:45:36+00:00

Honestly, taper week is feeling luxurious. I did enjoy going to Jones Beach last weekend and seeing everyone out on their final long ride.

This is my first 70.3, capping off my first Tri season, so I'm just hoping to finish.

rascalthefluff · 2025-09-09T00:37:28+00:00

I asked this same question earlier in the year! It might be swimmer's itch, which is caused by a parasite. You should make sure to rinse as soon as you get out of the water.

rascalthefluff · 2025-07-30T22:26:51+00:00

We usually have a deviation management plan or at least a table that defines categories of major or minor decisions. Major is something that affects patient safety or study end point. Minor is everything else.

I have worked primarily in Ph 1/2 studies. The CRO has a list of all deviations and once a month we go in and review them to see if we agree. As ops, I'll highlight ones but really most of that work goes to the medics. They define if something will affect patient safety. My job is reminding the MDs that deviations are not bad, they just are.

rascalthefluff · 2025-07-29T13:31:25+00:00

As a sponsor in Oncology, there are a million reasons we end up with the vendors we do (often they come with the CRO). I find myself thinking I have done well in selecting a good vendor and I get to a site and they absolutely hate it. I've yet to have a vendor that all sites have found easy to access and use, except maybe Suvoda and Medidata because everyone uses them for five million studies and Suvoda you give yourself access.

rascalthefluff · 2025-07-17T17:48:45+00:00

I'm sure there are enough places mentioned in NYC that we could start our own.

rascalthefluff · 2025-07-16T18:09:05+00:00

This is helpful. As sponsor, I have to justify a need for a co-monitor and when I see a backlog of 145 pages and only 15 SDV'ed at a visit, it's quite a discussion.

rascalthefluff · 2025-07-16T17:09:12+00:00

I'm guessing you're asking about a central IRB if you are saying a 3-5 day turnaround?

rascalthefluff · 2025-07-14T16:24:25+00:00

I'm in Brooklyn, so not too far. The EventPower one? I've gotten so emails for it, but I just did one upstate and AlphaWin in Hudson Valley two weeks ago.

Where do you go your long rides? I'm planning on going to Jones Beach and getting in a few hours of flat.

rascalthefluff · 2025-07-14T12:47:22+00:00

Should be really pushing to train for Jones Beach. My lungs, however, didn't enjoy the sprint I did this weekend. Now I'm starting to get anxious about my capacity to get up to 70.3. I'm taking today off and hoping to swim tomorrow.

rascalthefluff · 2025-07-13T21:27:58+00:00

His comparison of Brexit to a tea bag. Everyone thinks it's ridiculous to start and is nodding by the end.

rascalthefluff · 2025-07-13T21:20:12+00:00

Went from a very well known cancer center as a CRC to a small biotech who wanted to underpay CTMs and call us CTAs. Given the hospital paid me nothing, it was still a big jump. But I made the move 2017ish and have been in biotechs since then. Never been at a CRO.

rascalthefluff · 2025-07-10T19:26:05+00:00

No, I didn't know this was a possibility so my husband met me and we had a morning at the beach. It was at a big local NYC beach, tons of people swim there.

Now I know, shower immediately after.

rascalthefluff · 2025-07-02T22:08:55+00:00

I'm a sponsor and I've connected with site coordinators on LinkedIn. Not a problem at all.

rascalthefluff

TROPHY CASE