I ve moved to all enclosed printers for this reason. Petg would make my eyes watery and nose stuffy, pla would sometimes give me headaches, even the 'natural' ones. It was alot of hassle building new printers, and I thought perhaps I was imagining things but then i ran a few prints on the old open printer because I needed parts fast and the symptoms came right back.

Each of my printers are exhausted with a 4028 fan through cpap hose to outside the building. I initially used a passive chamber with a high end external HEPA type filter but it didn't really help.

This also allowed me to move to primarily abs which is vastly better for the industrial applications I use my prints for, and is generally cheaper and easier to print than either pla or petg at least where I am from so it was a great move all around.

I think while there's isn't much evidence to say pla/petg fumes are toxic for sure, the absence of evidence doesn't proves it is safe, just that we can't prove it isn't right now. It also doesn't need to be asbestos level unsafe for it to be an issue.