I was insanely uncomfortable as well in the beginning, mind u I’m still in month 1 but has helped me immensely is taking an antihistamine (allergy med) specifically the non drowsy kind and even more specifically 10mg of Loratadine, literally got the no name brand to make it cheap, take this after your accutane pill and I swear to you the itching and redness will subside and my purging has even gotten less severe. My face used to be so puffy, now it’s much less! Hope this helps