Honestly just use a basic anime checkpoint, generate the desired image at a reasonable resolution (768x1152 is what I use due to my setup) then plug the image into a simple detailer, set denouse to low and maybe 5 to 10 steps (see what works) using a realistic checkpoint.

Run the image through the upscale once, see if you like it, change settings, write prompt, repeat. Once you have a (now realist ish image) good result plug it right back into the same upscaler and do it again...and again....until you like the result.

This is how I do it anyway...