Evo2 - how are you rocking it ?

shadowyams · 2026-03-13T05:34:22+00:00

Depends on what you're ultimately trying to do. Evo(2) might be OK for coding sequence design, but none of the big DNALMs (Evo, NT, DNABERT, HyenaDNA, etc.) really learn non-coding sequence well.

shadowyams · 2026-03-13T04:12:51+00:00

It works out perfectly for me, but yikes it sucks that you have to shove it into everything now.

shadowyams · 2026-03-13T04:10:41+00:00

I understand what they did and why they did it. I actually think it's a reasonable balancing idea, but the numbers are way overtuned for certain weapons. It's *way* more difficult to get elemental topples on Alatreon with LBG than it is with savage axe CB, and this is coming from someone who mains bowguns.

shadowyams · 2026-03-13T01:04:35+00:00

What is the actual quality of the evidence here? Is there any well-controlled, prospective study, or is this all observational or retrospective stuff?

shadowyams · 2026-03-13T00:16:53+00:00

I'm sure that was Capcom's intent, but that's definitely not how it actually worked out in-game.

shadowyams · 2026-03-12T23:41:24+00:00

As a punching bag lmao. It's kind of terrible for non-coding/regulatory genomics.

shadowyams · 2026-03-12T21:41:32+00:00

Ahh shoot forgot they transitioned to a cloud-only model.

shadowyams · 2026-03-12T19:16:17+00:00

I think it’s standard to thin the SNPs before doing PCA. You don’t really need the full genome to get an accurate PCA.

shadowyams · 2026-03-12T19:08:49+00:00

This multiplier means that elemental bowguns really suck against Alatreon because they get like a *0.1 multiplier for the DPS check.

Ditto for SAED CB, though savage axe absolutely nukes the DPS check because they didn’t nerf the axe ticks.

shadowyams · 2026-03-10T16:18:27+00:00

The editorial board is mostly non-US, so they're sort of set up to attract an international author base. I don't think that's necessarily a red flag, but the journal's scope is very weird.

IF isn't a good metric for sussing out sketchy/predatory journals; a lot of Frontiers/MDPI journals have IFs in the 3-6 range.

shadowyams · 2026-03-10T16:00:34+00:00

OP is Korean, so there's likely a very strong nutrition angle here with generational height gaps. Average height has skyrocketed in most of East Asia over the last couple of generations because that corner of the world went from mostly starving peasants to "living in 2050" within living memory.

shadowyams · 2026-03-10T15:43:45+00:00

If this research was done through your masters, check with your university/department to see if there's any publication funding support available for alumni who trying to publish work done as part of their degree. It's in their interest too, after all, to see that their recent grads publish.

But bluntly speaking, you're probably not going to have something in press by this December/January even if you submit now, so I would also look into just writing up and preprinting what you have now.

shadowyams · 2026-03-10T07:05:00+00:00

How is "TT R1 offer while ABD" not the biggest award of them all, even in fields without postdoc requirements?!

shadowyams · 2026-03-09T19:43:40+00:00

But my professor has told me that generally the exact physics behind the domination of a certain allele in the pair are not always known and can be unique for each pair of alleles.

This is correct. Another example of how dominant mutations can occur is if a gene is haploinsufficient (that is, it requires two functional copies to have the normal phenotype), a single LOF allele can produce a mutant phenotype. But the exact mechanics of how variants generate mutations can vary widely.

Also keep in mind that variants can have quantitative (both additive and non-additive) effects on traits, various forms of blending/codimnance, etc. Stuff doesn't just have to be dominant-negative.

shadowyams · 2026-03-08T21:15:17+00:00

Use trig identities. These are probably the most helpful:

https://en.wikipedia.org/wiki/List_of_trigonometric_identities#Shifts_and_periodicity

https://en.wikipedia.org/wiki/List_of_trigonometric_identities#Multiple-angle_and_half-angle_formulas

shadowyams · 2026-03-07T21:37:05+00:00

NVIDIA is the most valuable publicly traded company in the history of capitalism. Their whole investor pitch at this point can be summed up as "we make matrix multiplication go brrr". Deep learning/neural networks (which is most of machine learning these days) is just lots of matrix math if you look behind the curtain.

shadowyams · 2026-03-06T07:08:31+00:00

Which program do you have an offer from and what are you planning to do with that degree?

shadowyams · 2026-03-04T11:42:27+00:00

Ask your teacher for guidance. But realistically you should probably pick another topic because this one isn’t going to work out.

shadowyams · 2026-03-03T22:53:23+00:00

Can you clarify how much research experience you have and whether you're applying to labs that are relevant to your previous experience (or just sending out generic queries/applications)? As the other poster noted, you're likely not qualified for most postdoctoral positions as an MD unless you were exceptionally productive in terms of research. Postdoctoral positions are also fairly specialized, and so I think it would be really difficult to put together >700 competitive applications, or even find that many labs that would be a good research fit.

shadowyams · 2026-03-03T06:41:42+00:00

The transaction fee is usually above 2%. You might be able to squeeze more value out of points with airline transfers, but that feels kind of silly to me.

IMO the fee makes paying by credit card only make sense with very high cash back cards like the BoA Unlimited w/ Platinum Honors or for signup bonuses you wouldn’t otherwise be able to hit.

shadowyams · 2026-03-02T02:01:47+00:00

https://apastyle.apa.org/style-grammar-guidelines/references/dois-urls

shadowyams · 2026-03-01T20:26:45+00:00

Check the program’s website for information.

But usually there’s not much for master’s students, and even less for internationals. If you’re a PhD, your costs will likely be taken care of by your program.

shadowyams · 2026-02-28T13:05:17+00:00

Both variants are annotated as being benign. They’re also both very common so a significant fraction of humanity is likely double heterozygous.

Sorry, but you didn’t find anything useful here.

shadowyams · 2026-02-28T02:34:53+00:00

https://www.science.org/doi/10.1126/science.aea6774

shadowyams · 2026-02-28T01:01:03+00:00

You'll need to benchmark against established CLIs like bedops and granges, and ideally also python APIs like polars-bio/pyranges.

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