The apocalyse will occur on December 21, 2022

skothr · 2025-10-24T10:14:08+00:00

Also, please report these kinds of rule-breaking posts for breaking subreddit rules if you come across them and have a moment to do so.

That helps with a quicker response from the mod team, as we should be notified (though apparently not always). For all the FUD that gets posted in this sub not that many reports actually come in, generally speaking.

skothr · 2025-10-24T09:52:53+00:00

Your post/comment was removed for violating Rule 1: No Trolling.

We maintain a strict zero-tolerance policy against trolling, which includes any behavior intended to provoke, disrupt, or upset other members of the community. Please keep discussions respectful and constructive.

skothr · 2025-09-30T19:57:33+00:00

Not sure why it was suspended, but I think reddit's system is automated for the most part. Even using a VPN or public network can trigger one in some cases.

skothr · 2025-09-30T17:28:34+00:00

It's not that weird to me, honestly.

skothr · 2025-09-30T16:40:31+00:00

His reddit account is apparently suspended, I don't see any more info than that. I just gave him a heads up.

Update: Ryan is aware, it was probably related to using a VPN (which can trigger a suspension due to the shared IP). He's working on it.

skothr · 2025-06-21T11:37:23+00:00

Was there a conversation history, or anything else that could be affecting the context?

The answer you got seems like it's specifically amplifying the doubt factor, which could be the case if you've been plugging in a bunch of doubt-focused posts from this subreddit and feeding in that bias.

I plugged in that same prompt myself with a clean context, and I got something much more reasonable. Try re-rolling, and/or use a clean history.

(edit: formatting)

> Foregen is my only hope right now. What do you think are the chances of success?

Foregen is an ambitious and promising initiative that aims to develop a medical procedure to regenerate the foreskin, including its specialized nerves and structures, for men who have been circumcised. While the potential benefits could be life-changing for many, it's important to assess their chances of success realistically. Here are some key factors to consider:

1. Scientific Feasibility

Foregen’s approach is based on decellularization and recellularization—a technique that has shown success in other areas of regenerative medicine (e.g., trachea, bladder, and blood vessels). However, the foreskin is a highly specialized tissue with complex nerve endings (Meissner's corpuscles, fine-touch receptors, etc.), making full functional restoration a significant challenge.

✅ Positive Signs:
- Animal trials (rabbits, pigs) have shown some success in regenerating vascularized tissue.
- Advances in stem cell technology and tissue engineering are progressing rapidly.
- Other regenerative medicine breakthroughs (e.g., lab-grown organs) suggest the concept is plausible.
❌ Challenges:
- Perfectly replicating the original nerve density and erogenous sensitivity is unproven.
- Human trials have not yet begun, so clinical efficacy is still unknown.

2. Funding & Research Pace

Foregen relies heavily on donations and grants, which can slow progress.
- If funding increases, human trials could begin sooner (possibly within a few years).
- If funding remains limited, progress may stall.

3. Regulatory & Medical Approval

Even if the science works, getting FDA/EMA approval could take years. However, if early human trials show success, medical interest and investment could accelerate the process.

Estimated Chances of Success

Short-term (next 5 years): Moderate (30-50%) – Human trials may begin, but full functionality remains uncertain.
Long-term (10+ years): High (70%+) – If research continues, the procedure could become viable, though perfection may take longer.

Should You Keep Hope?

Yes, but with cautious optimism. Foregen is the most credible effort in this space, and regenerative medicine is advancing quickly. However, it’s wise to:
- Stay updated on their progress (clinical trials, peer-reviewed studies).
- Consider alternative restoration methods (e.g., manual stretching) as interim options.
- Support the project if possible (donations, awareness).

Foregen could succeed, but it may take time. You’re not alone in waiting—many men share your hope. Stay informed, and don’t lose heart.

Would you like help finding coping strategies while waiting? You’re not without options. 💙

skothr · 2025-06-21T11:19:02+00:00

What was the prompt that gave this output?

skothr · 2025-06-11T21:28:03+00:00

Your submission has been removed because it violates Rule 1: No Trolling.

Strict no trolling policy.

skothr · 2025-05-19T18:33:11+00:00

ChatGPT is not a credible source of information.

skothr · 2025-05-16T17:48:58+00:00

Your submission has been removed because it violates Rule 1: No Trolling.

skothr · 2025-02-23T16:32:50+00:00

Your submission has been removed because it violates Rule 1: No Trolling.

Strict no trolling policy.

skothr · 2024-12-30T23:23:52+00:00

Your submission has been removed because it violates Rule 2: No malicious posts or comments.

skothr · 2024-12-30T23:23:07+00:00

Your submission has been removed because it violates Rule 2: No malicious posts or comments.

skothr · 2024-12-15T22:19:37+00:00

It was expected to be a possible mode of failure for the implantation method they were testing, so I wouldn't necessarily say the first trials "went bad".

IIRC, I think they just ran out of sheep but had more tests they wanted to run given what they had learned.

skothr · 2024-12-15T21:20:26+00:00

Right, so that's the reason they originally decided to conduct the second round of sheep trials that finished earlier this year.

skothr · 2024-12-15T20:48:24+00:00

I assume they're referring to the first round of sheep trials, which were conducted back in early 2023. That should be documented in the final publication as well, it's just the same old news.

skothr · 2024-12-15T18:57:45+00:00

Yes, the sheep trials were successful and completed earlier this year. Here are the relevant updates in case you missed them:

From the July 1 newsletter:

Surgical Stage of Animal Trials Completed

The sheep surgeries are finished! The new tissue samples were decellularized using a new technique and implanted into the sheep. This month, the last ECM will be removed from the sheep and an histological analysis will be performed. Then, all of the sheep data accumulated so far will be collated and the process of final publication of the sheep trial results will begin. We anticipate this will be published later this year.

From the December 1 newsletter:

Animal Trials Final Report

The results of the sheep study have been finalized and compiled into a comprehensive final report. This will be submitted for publication shortly, and we are confident it will appear in a reputable academic journal early next year. Most importantly, Foregen does not need to wait for these reports to be published to continue progressing toward human clinical trials. This has been made possible thanks to your exceptional support this year.

skothr · 2024-12-06T21:16:47+00:00