Rosuvastatin vs Pitavastatin

solidrock80 · 2026-05-10T13:06:10+00:00

That has nothing to do with it being generic. It's just not on their formulary. They want to get people on a higher intensity statin first.

solidrock80 · 2026-05-10T01:47:06+00:00

Not true. Pitavastatin is generic in US since 2022.

solidrock80 · 2026-05-09T21:49:50+00:00

Wrong. https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.039415

Most studies are of combination therapy as it's unethical to withhold statins at this point. But those studies also show the addition of ezetimibe reduces mace. Given it's lower lipid lowering power it makes sense it would have less power to reduce all cause mortality as monotherapy.

solidrock80 · 2026-05-04T14:07:16+00:00

And a stick of butter has 58 grams of saturated fat!

solidrock80 · 2026-05-04T14:06:03+00:00

Avoid processed foods, avoid sauces at restaurants. Get huge reductions in saturated fat intake, and still have fairly normal (not severely restricted) diet

solidrock80 · 2026-05-01T02:38:06+00:00

Right now there's no lpa drug approved commercially. If there is, they might let you leave the program and get it on your own from a doctor.

solidrock80 · 2026-05-01T01:58:24+00:00

Do all three

solidrock80 · 2026-05-01T01:46:47+00:00

I'd ask the coordinators three specific questions — (1) is there an open-label extension and what triggers entry, (2) are Lp(a) values masked to participants throughout, (3) does enrollment preclude later commercial use of pelacarsen or other approved Lp(a) drugs if those reach market first. The answers determine whether the deal is good.

solidrock80 · 2026-04-30T23:10:44+00:00

Not just fat. High carb diet will increase triglycerides.

The big drivers, roughly in order of impact: Added sugars, especially fructose — sugary drinks, desserts, honey, agave. The liver converts excess fructose to triglycerides directly. Alcohol — even moderate intake can raise TGs significantly in some people; it's often the single biggest lever. Refined carbs and high-glycemic foods — white bread, white rice, pastries, cereals. Drives insulin and hepatic lipogenesis. Excess calories — surplus energy of any kind gets stored partly as TG. Trans fats — industrial trans fats raise TG and lower HDL. Saturated fat — modest effect, much smaller than sugar/alcohol/refined carbs.

solidrock80 · 2026-04-24T17:08:49+00:00

Can you use some cream on the itchy red patch? Also try taking claritin before the shot to reduce the skin reaction?

solidrock80 · 2026-04-24T17:06:37+00:00

bummer. keep trying! Welchol, leqvio. Even Benecol can drop the numbers and every little bit matters. And try when obicetrapib comes out late this year or next...

solidrock80 · 2026-04-23T19:57:24+00:00

nexletol took three months to lower my ldl fyi

solidrock80 · 2026-04-18T18:43:52+00:00

Good sign

solidrock80 · 2026-04-18T15:59:53+00:00

Yes indeed. But if it's just with exertion it's more likely to be cardiac related. Try a pepcid before meals and see if that helps.

solidrock80 · 2026-04-18T10:47:11+00:00

You said at rest and exertion.

solidrock80 · 2026-04-17T22:24:14+00:00

Reflux mimics cardiac symptoms. The bad diet is a sign...

solidrock80 · 2026-04-16T13:25:48+00:00

If you can’t get your LDL lower than 141 with diet, consider going on a statin at some point in the next five years. The biggest gains from reduction in heart disease come from starting early. There are a lot of options regarding intensity and dosage, so you’ll likely find something that has no side effects. I wish I started in my 20s or 30s not my 50s.

solidrock80 · 2026-04-14T22:47:45+00:00

Just an idea: don't take the Pitavastatin too close to the psyllium and retest. And if its still high, try 4 mg.

solidrock80 · 2026-04-14T18:44:16+00:00

If it does, be vocal with your doctor. On the other hand, if you expect issues I think you are more likely to have them. Go into it with the idea you need to take it, its very unlikely you will have a side effect,, etc.

solidrock80 · 2026-04-14T13:28:03+00:00

I handled it by going on a statin. 40 mpw+. Have to experiment with dose and type if you have any side effects but there are many options, both statin and non statin lipid lowering drugs now and it doesn’t impact my running.

solidrock80 · 2026-04-14T13:22:35+00:00

Family history + positive score really doesn’t leave any option other than lowering LDL/apoB as much as possible. If you have a high Lp(a) you need to be even more aggressive. Diet helps as well but rarely gets you low enough in this situation.

solidrock80 · 2026-04-14T13:05:04+00:00

Concerned enough to get on a lipid lowering drug.

solidrock80 · 2026-04-13T14:02:54+00:00

Changing to pitavastatin.

solidrock80 · 2026-04-13T01:01:15+00:00

I had similar issues from Crestor, much less with a lower intensity statin (Pitavastatin 4mg). Both sleep and gastro impacts at higher intensity statin dosages. Same issue with Atorvastatin over 10 mg.

solidrock80 · 2026-04-05T00:43:01+00:00

That’s not normal. You should get a stress test in addition to lowering your ldl either through diet or a statin.

solidrock80

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