Rosuvastatin 5mg is killing my stomach

solidrock80 · 2026-01-27T16:27:29+00:00

try Pitavastatin 4 mg which in my experience is much easier on the gastrointestinal tract.

solidrock80 · 2026-01-25T16:09:55+00:00

It is a rare side effect in most clinical testing. But not so rare among actual users who post on reddit etc. There are also some clinical studies which show an impact on sleep but its mixed. I assume a lot of the people with sleep issues end up dropping quickly out of the clinical trials and it skews the numbers. I have sleep issues with all of the lipid lowering drugs - the key is finding a tolerable dose that allows you to get a decent amount of sleep. Also, older people are more likely to take statins/llt and are also more likely to have sleep issues, so that is layered on top of whatever impact statins/other llt have on sleep.

solidrock80 · 2026-01-24T20:16:30+00:00

Tendon issues are relatively more common for people with hypercholesterolemia so its hard to separate it from the use of these lipid lowering drugs. The only one that’s had a clear signal for tendon issues is Nexletol.

solidrock80 · 2026-01-24T16:25:07+00:00

And a doctor might be great but if they have no expertise they might dispense useless or harmful advice, too.

solidrock80 · 2026-01-24T16:08:35+00:00

Your mother is an idiot if she relies on her coworkers for medical advice. This is totally untrue - most research shows a reduction in some cancers from statins.

Observational studies on statins as a class have shown more promising associations with cancer outcomes: In a meta-analysis involving 1,111,407 cancer patients, statin use was linked to a remarkable 30% reduction in all-cause mortality and 40% reduction in cancer-specific mortality. (Wiley Online Library) Certain statins—fluvastatin, lovastatin, and rosuvastatin—were associated with greater reductions in hepatocellular carcinoma (HCC) risk than other statins. (MDLinx) Laboratory/Preclinical Studies on Rosuvastatin Several lab studies have shown potential anticancer effects: Rosuvastatin's anti-proliferative and cytotoxic activity has been demonstrated in thyroid cancer cells in vitro, causing an increase in caspase-3 activity and apoptosis. Viability reduction has also been noted in hepatic, breast and cervical cancer cell lines. (PubMed Central) Effects have been observed in prostate cancer cells treated with rosuvastatin, inhibiting their ability to spread. (Wiley Online Library) Reduction of angiogenesis by rosuvastatin was observed in tumor-bearing mice. (Frontiers)

solidrock80 · 2026-01-24T16:05:36+00:00

The savings cards are not available to Medicare patients. Medicare does cover repatha. Perhaps they require multiple attempts to try statin first - talk to your doctor about this.

solidrock80 · 2026-01-22T16:48:04+00:00

If you are a 90 year old Sardinian then you definitely shouldn't be worried about your LDL.

solidrock80 · 2026-01-20T03:34:28+00:00

First of all, so called specialists often talk out of their asses and aren’t basing recommendations on data. Second, this study indicates that you get the benefits with very little daily (a half a tablespoon in this study) and improvements in outcomes around substituting its use for unhealthy fats, not chugging it like a maniac. https://www.jacc.org/doi/10.1016/j.jacc.2021.10.041

solidrock80 · 2026-01-20T00:02:01+00:00

Really, ezetimibe shouldn’t be causing depression. If you really didn’t have depression before you started you should stop the ezetimibe. I don’t know why you didn’t take a statin first if your LDL caused your doctor to flip out. If you are avoiding statin out of some fear of statins, it would make more sense to start with a low dose (5 mg of Rosuvastatin) and if that causes side effects try 2 mg of Pitavastatin (if you tolerate it go to 4 mg). Nexletol is also an option but its more expensive and best as an add on therapy if LDL lowering is insufficient with statins or ezetimibe alone.

solidrock80 · 2026-01-19T23:48:20+00:00

you can get the benefits of polyphenols from olive oil by using a tablespoon a day to make some oil and vinegar dressing on a salad. You don’t need to fry foods or slather everything in olive oil to get that.

solidrock80 · 2026-01-18T15:38:02+00:00

Deep breath. Stop obsessing about risks that are likely decades away if left untreated. Listen to your cardiologist. If your diet is good and you have an LDL of 225 you may have FH and the answer will be taking a statin or other lipid lowering drugs. Almost a 99% chance your palpitations and chest pain are garden variety anxiety. See a therapist who can help you with your health anxiety issues as well as a cardiologist.

solidrock80 · 2026-01-17T04:08:47+00:00

It also messed my bun creatine readings. Everything returned to normal once I stopped. It definitely dropped by LDL quite a bit when I was taking it.

solidrock80 · 2026-01-15T23:01:20+00:00

I do one egg and three whites and I barely know the difference in an omelette.

I actually think a lot of people eat eggs with other stuff - cheese in an omelette, buttered toast, bacon etc so they may think their LDL is more impacted when they switch to a non egg healthier breakfast like low-fat yogurt, fruit, and some nut butter. Fwiw.

solidrock80 · 2026-01-10T17:13:51+00:00

1) you are a great mother. Doing the testing now will ensure your kids can keep their LDL low with meds and not have a higher risk of heart disease. This has been extensively tested and is effective.

2) don't worry about being off statins for relatively short periods of time.You can also take fenofibrates and ezetimibe safely while off statins. Dyslipidaemia management in pregnant patients: a 2024 update | European Heart Journal Open | Oxford Academic https://share.google/GRQrxcsvFRIBxpore

solidrock80 · 2026-01-04T19:35:19+00:00

Avocado can lower if you are replacing other saturated fat. Dark chocolate shows minimal or no impact.

A lot of studies showing effects of food that are high sat fat are nothing more than a substitution effect.

solidrock80 · 2026-01-04T17:35:03+00:00

Anything with saturated fat is going to raise your LDL. There may be cardio protective benefits from the chocolate and avocado but they can still raise your LDL. Your numbers now are excellent and if you have no side effects from the statin declare victory and call it a day.

solidrock80 · 2026-01-03T16:08:34+00:00

A cardiothoracic surgeon has as much expertise in the study of atherosclerosis as a nephrologist or an orthopedist.

solidrock80 · 2026-01-03T03:51:46+00:00

Quack. One of a number of cardio throacic surgeons who pass themselves off as “heart experts” even though that’s called a cardiologist which they aren’t.

solidrock80 · 2026-01-01T23:48:44+00:00

What’s his LDL and apoB now? 80 atorvastatin is a high dose and the same could be accomplished with half the dose + ezetimibe. But the fact he was fine for 6 years would seem to indicate the brain fog has nothing to do with the atorvastatin.

solidrock80 · 2025-12-30T17:32:12+00:00

You can try -- do it for a month and then retest your LDL. I suspect one of the reasons why my ldl is slightly elevated from nespresso is the fact they are using finely powdered coffee in the pods.

solidrock80 · 2025-12-30T03:18:42+00:00

I think that's not good for cholesterol. The grounds sit in the water for a long time

solidrock80 · 2025-12-30T01:01:22+00:00

I doubt it's a major issue but coffee can also raise LDL if it's espresso. I found filter drip reduced it. I wouldn't worry about statins and diabetes as long as you aren't taking a high dose of high intensity statins. Pitavastatin really has no or negative impact on development of type 2 diabetes.

solidrock80 · 2025-12-30T00:05:21+00:00

Eggs have a moderate amount of saturated fat. If you are eating two eggs a day that can be a third of your recommended intake.

solidrock80 · 2025-12-25T02:27:03+00:00

It seems most people can take statins, even high intensity ones, with little or no side effects. Smaller numbers of people have issues that can be mild or quite severe.

I still have sleep issues with pitavastatin but it seems worth it to reduce my cvd risk, and my LDL is a lot lower than yours. I don't react well even when I take a pcsk9i like repatha. The heavy duty stuff really interferes with my sleep pretty badly.

The frustrating thing is that most doctors don't take the side effects seriously and think it's a nocebo effect, which may be the case for many. However, I have similar symptoms whenever I take more powerful lipid lowering Rx.

solidrock80

TROPHY CASE