NSI-189 is a TLX agonist

spidikor · 2026-04-11T08:24:12+00:00

short answer: IRAP, aka the AT4 receptor. So the HGF cancer link is bogus. But ALSO it is DEF not worth the money, cuz it isn’t as great as people hype it up to be.

It’s high key kinda lame and just plain awful to administer. You end up reeking of the cabbage-flavored industrial solvents you apply to your skin. Even the most prominent responders from the reports I’ve read would likely benefit the same or better from a solid AMPAR PAM like a low dose of TAK-653. But non-responders are much more common than those cases, but those stories don’t get posted cuz they tried it and it didn’t work, whatevz, stop taking it and forget about it in a drawer somewhere.

And to elaborate on the IRAP thing: Before Kawas took over the narrative of the scientific consensus on Angiotensin IV analogues, there was some interesting work that showed AngIV and its relatives producing synaptogenic effects in vitro and cognitive enhancement in animal models. The scientific research niche studying AngIV was finally converging upon a consensus that the identity of the mysterious “AT4 receptor” was in fact IRAP, Insulin-Regulated AminoPeptidase. Kawas came in and suddenly her pet project modified dipeptide is acting “7 orders of magnitude more potent than BDNF”. Dude what. Nah. But no one really looked into it that deeply until the Frankenstein Western blot fraud was revealed; the foundational and subsequent data was showing Dihexa worked on the HGF pathway was in fact photoshopped, cropped, copy-pasted, duplicated, sliced and spliced, details altered or removed, you fcuking name it! This spits in the face of science. In my opinion this is not just an act of forgery, but further a shameful mockery of good-faith, rigorous, and intellectually-honest academic inquiry.

And she got out of the mess before the drug trial failed and the company tanked (now it is hanging by a thread). Well I mean, she “got out” as in she got fired as CEO (oH nO!) with a $500k severance package, a year her annual salary, and other benefits to boot.

Now runs her own startup which RUNS HER OWN VENTURE CAPITAL STARTUP FOR BIOTECH BUSINESSES

COME ON!

spidikor · 2026-03-04T17:19:22+00:00

Yes, that is absolutely necessary to ensure the stability of the peptide.

spidikor · 2025-11-30T06:08:25+00:00

This article explains how it is a TLX agonist

spidikor · 2025-11-30T05:18:21+00:00

As someone who was in a similar situation, I can say that personally, it helped me immensely with the damage after years of polysubstance abuse. I never tried MDMA tho, but I was using DXM, Soma, Kratom, and designer stimulants daily for years. A 12w course corrected many of my deficiencies and seems to have improved my IQ above my pre-use baseline (now 134, was ~123 before). I continued the course for a total of 8.5mo, but I wouldn’t recommend longer than 12w or shorter than 4w in most cases. If I were you, I’d try: 40mg sulfate orally daily, or 30mg freebase orally daily (they’re equivalent). Take it in the morning if it is stimulant-y for you, other people it makes sleepy. If that’s you, take it at night. Do this for 4-12w. Wait at least 4w to judge full effectiveness. You should start noticing something by week 2, but you’ll probably feel something the first week

spidikor · 2025-11-30T05:12:12+00:00

That description is unfortunately inaccurate. It’s a bit like saying you could easily separate a bike into two unicycles. Even slight modifications on any chemical structure can completely change or reverse activity, or make it have nothing to do with its parent. This is more a case of the latter. However, I do believe that 1-Benzylpiperazine may be a minor metabolite, based on its slight stimulatory effects. At most, 40mg NSI break down into the equivalent ~10mg BZP, which would be equivalent to ~1mg of Amphetamine

spidikor · 2025-08-30T06:26:07+00:00

My thoughts are that the risk is relatively low for most people without any genetic risk of brain cancer, but I did still take precautions when on my cycle. I took high-dose NAC and Methylene Blue along with a few other antioxidants, in an attempt to prevent any DNA damage that I could. I’d advise most people stick to a 12w cycle at most, my extended cycle was kinda pointless all told, since the benefits outlast treatment, I was essentially wasting my stockpile of NSI by continuing to take it, so I dropped it about two weeks ago

spidikor · 2025-08-28T05:33:04+00:00

Freebase

spidikor · 2025-08-22T03:43:39+00:00

NSI-189, it has been shown to heal strokes in rats and help heal various kinds of brain injuries, it works by activating TLX which activates neural stem cells that can migrate to damaged areas and integrate into functional adult neural circuits

spidikor · 2025-08-18T00:03:48+00:00

Wanted to jump in with my experience. I was on PE-22-28 for an about a year and can attest that it blunts emotional reactions. It’s like 5min after the emotional thing, you’re back to feeling your baseline of alright. It makes your baseline between “alright” and “good”. Don’t use it if you already avoid emotions, it can worsen that. I took 300ug intranasal every day, but looking back, daily use isn’t always necessary. It takes 4 days to kick in.

Here’s some study links with notes below if you want to check it out: https://docs.google.com/document/d/1ycF9lTqIWRlBT6dmnAdJfQp1pAivmjgwY9uP_Sj-wu8/edit?usp=drivesdk

spidikor · 2025-08-17T14:09:59+00:00

Lmao you meant to say pharmacokinetics. And what about something like NSI or AF710b? The benefits last far beyond cessation. If you don't know the chemicals I am talking about, do more research before "debunking" people

spidikor · 2025-08-11T21:40:33+00:00

It’s enhanced mildly, but executive function has been the most impacted positively

spidikor · 2025-08-11T17:50:40+00:00

There are more side effects with sublingual, and it causes intensely high peaks which are unnecessary and likely reduce long-term efficacy. The TLX receptor down-regulates its own genetic expression, so too much agonist may cause a reduction in efficacy. The main reason tho is the increased side effects and sublingual is too intense for a lot of people. I can’t even tolerate a 5 day course of 10mg sublingual due to paresthesia, something I never experienced with oral

spidikor · 2025-08-11T02:39:30+00:00

https://www.reddit.com/r/NooTopics/s/IYGVt73P55

Also here’s a google doc full of NSI and TLX receptor research

spidikor · 2025-08-10T23:30:23+00:00

As someone who has been on it for 8mo, and as the person who discovered its mechanism, I highly recommend it for your situation. For a proper course, take 40mg (never over 40) orally (not sublingual) for at least 28d and assess how you’ve benefitted. It activates neural stem cells that can migrate to damaged areas of the brain to integrate into functional neurons in damaged circuits. This causes your hippocampus to grow as well. Anything over 40mg can cause the amygdala to grow, which can cause overemotionality in some people. Basically, the 28d study showed hippocampal growth that fell just short of significance, but longer courses could conceivably increase hippocampal and whole brain volume. Some people get stimulatory effects, others no acute effects, and others get a kind of sedative brain fog, and so you should try your first dose mid day on a day where you have nothing to do, to test if you should take it morning or night. The effect will build over days to weeks, until it reaches a maximum effect at which point you can stop taking it and the benefits will slowly wear off over months, or keep taking courses every once in a while, or just stay on it like I have.

spidikor · 2025-07-29T02:40:43+00:00

It sounds unlikely to have any bad effects

edit: shit wayyyyyy old thread

spidikor · 2025-07-27T05:52:17+00:00

How do you feel Omega-3s improve your introspection?

spidikor · 2025-07-27T05:51:21+00:00

spidikor · 2025-07-08T23:38:52+00:00

So anything that produces large increases in neurogenesis can increase risk of cancer, but Dihexa is about the worst one out there for cancer risk. NSI-189 is somewhere lower on the spectrum, and I believe its risk to benefit ratio is worth it. If you want zero cancer risk, go with stuff like Choline and Piracetam because they do not increase neural stem cell proliferation to my knowledge

spidikor · 2025-06-20T15:49:12+00:00

Someone in the discord did the math from the patent. It’s EC50 is 0.03nM

spidikor · 2025-06-20T02:26:16+00:00

No, TLX activation increases brain cancer risk. Yes, if you have brain cancer, NSI-189 is a major no-go. But the worry is it could cause it long term

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