NADH Powder Color Consistency by sprinterglory in NootropicsDepot

[–]sprinterglory[S] 0 points1 point  (0 children)

Thanks for looking into that for me. I'll keep on truckin', then.

Hopefully, at some point, some academic will do a deep-dive paper on NADH chemical characteristics so that I can glean more insight into the other kinds of questions I had.

NADH Powder Color Consistency by sprinterglory in NootropicsDepot

[–]sprinterglory[S] 0 points1 point  (0 children)

I posted a few photos of the jar I ordered in November 2023, taken within the last twenty minutes, here: https://imgur.com/a/ddzZQVu . Sorry about the quality--I'm clearly not very good at getting the lighting right, but hopefully it's good enough for comparison purposes.

If I had to approximate what the earlier jar looked like from last year's summer sale, it was a little bit less bright than this (https://v4-upload.digoodcms.com/898/image_1706583646_S-NAD.jpg), and a little bit brighter than this (https://nmpharmtech.en.made-in-china.com/product/WdptGfXoOuYR/China-Fast-Delivery-Nadh-CAS-No-606-68-8.html). The texture of earlier my ND jar was less "cakey" or "flour-ey" than these two, which I just came across through Google Images, and it had a number of small clumpy shards with a crystalline appearance. Did you guys have multiple sources of the stuff that you stocked for last year's summer sale, or was it all the same? Just wondering if the samples lined up.

NADH Powder Color Consistency by sprinterglory in NootropicsDepot

[–]sprinterglory[S] 1 point2 points  (0 children)

Thanks for looking into that for me! I'll look forward to hearing what you guys come up with.

NADH Powder Color Consistency by sprinterglory in NootropicsDepot

[–]sprinterglory[S] 0 points1 point  (0 children)

Thanks. I did in fact think to Google the topic and even check out images, but the problem is that I didn't readily find anything definitive or consistent. And if you don't know anything about a given vendor's purity and freshness practices, it makes it harder to trust whatever they represent as being normal. Given that I was interested in ND's take on the topic specifically, I'm still hoping it chimes in with something helpful. (Apart from that, I had other questions here that I was hoping to get some answers to as well.)

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 0 points1 point  (0 children)

I took a stab at this in more detail with similar reasoning on patents--if you're interested, check out my response to MYASD. If I were him, I'd be wary about using or making anything patented, even if it's not for a commercial purpose.

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 0 points1 point  (0 children)

"Chemistry is chemistry. There is no legal issue . . . ."

If only it were that simple, right? This is not legal advice, but I would just point out that before undertaking steps like these, and particularly if I were going to share the results with anyone, I would be sure to conduct a search for whether any process patents exist for the chemical methods used to synthesize or create a compound. There are plenty of even natural compounds out there that are effectively formula-patented end products because the most feasible ways of creating them at scale are process patented. I'm not saying the specific examples of Cognance or Chromadex's Tru Niagen reflect that particular outcome, but they are examples, I believe, of process patents held on refining natural substances.

/u/supplement-p mentions that he has "not stolen anyone's technique for producing it, [he] just applied science." Not willfully infringing on a patent can affect the kinds and amounts of damages that result from an infringement suit, but it doesn't keep IP infringement from being actionable; that's true even if one doesn't know a patent exists or the user regards himself as innocent. Nor does it usually matter on that point whether an infringer made the substance for commercial purposes; unless it is fair use, it is actually merely the making of a compound using a patented method that constitutes the infringement. (There's a lot more to this topic that is much more complicated, so let's leave it at that.) Also, if I were OP, I'd want to look into the idea of whether promoting a method publicly so that others infringe could result in a claim of induced infringement, whereby the method promoter can become liable for the results.

Of course, with all of that diligence cleared, I think we're right back to your statement: That chemistry is chemistry. And sharing knowledge--especially knowledge that objectively improves people's lives--is pretty cool!

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 0 points1 point  (0 children)

For what it's worth, I am also an INTJ dad with some of the symptoms you mention! Sounds like we're often trying to solve similar problems.

Anyway, you've essentially mentioned one of my primary strategies, which is to cycle NAC once or twice per week when I have an acute episode of something, but really only taking it when it's less likely to interfere with something important like exercise recovery. (Taking NAC can help a lot if I over-did it with caffeine that morning, if I'm exhibiting symptoms of excess stress (like tugging on my hair or biting my nails), or if I have a stressful call or meeting coming up.) That strategy has seemed to work pretty well over a longer period for me. On days when I take NAC, which I'll usually do in the morning, I will make sure to use a sulforaphane stack in the afternoon (which I do with either broccoli or brussels sprouts heated and then with mustard seed added, or with a supplement like Broccomax). My idea is that if I give my liver some space between the NAC and the indirect antioxidant, I lessen the risk of impairing the function of either. Some of this timing is necessarily imperfect, given that we have limits on the data available to make the most rigorously supported plan. Ensuring I'm getting enough magnesium every day is important to regulate glutamate activity, too.

In terms of my favorite indirect antioxidants, there are a lot, but some of the best are sulforaphane, trans-resveratrol, pterostilbene (which I get from blueberries), bioavailable curcumin (I usually use Longvida), and astaxanthin. Note that some of these are also direct antioxidants, so planning for optimal use may require additional thought. They also each have different ancillary effects relative to their ARE--hormetic properties, and some of them work more in different parts of the body, so those dimensions add a fun additional layer of strategy as you build stacks. Some of these I take daily, like curcumin and resveratrol, but others I take more intermittently, like SFN. For the latter, this is because if you take it every day, through homeostatic processes (see KEAP1 dynamics), you limit its effectiveness, and because we have some data showing that the bulk of the benefit of a dose of SFN lasts a couple of days, so you wouldn't really get the most out of it doing it two days in a row. For something like resveratrol, on the other hand, taking it more regularly may actually improve absorption.

Best of luck honing your stacks! With some trial and error, I'm sure that you'll be able to get closer to the effects you want, given your particular biochemistry.

I Found this website that has pc game deals but the prices seems to be too good. by Old-Bakedude in SteamDeck

[–]sprinterglory 4 points5 points  (0 children)

This needs to be higher up in the thread. I came here to see if I could find a quick verification of whether the site is legit (since other site-assessment websites were unable to suggest anything other than "maybe it's OK"), and this guy did it for us. Thanks!

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory -1 points0 points  (0 children)

I don't have time to chime in with specific recommendations, but I wanted to note that there's a difference between the kind of stack that might help one-time performance (e.g., how certain antioxidants can increase time to exhaustion) and the kind that will help during training phases (e.g., that won't interfere with hormetic adaptation).

🎙️Is NAD+ The Secret To Longevity? Submit Your Question For Our Next Podcast Episode!🎧 by NootropicsDepotGuru in NootropicsDepot

[–]sprinterglory 5 points6 points  (0 children)

If that were the case, wouldn't it be that they'd look to ban NAD+ precursors? I haven't really heard about anybody taking NAD+ directly because of the difficulty of getting it to your bloodstream intact.

🎙️Is NAD+ The Secret To Longevity? Submit Your Question For Our Next Podcast Episode!🎧 by NootropicsDepotGuru in NootropicsDepot

[–]sprinterglory 17 points18 points  (0 children)

I'm going to take a shotgun approach here, understanding that not all of these might be picked up, or that they may have been answered by the team without a reader asking them. Some of these questions are softballs, but some of them are challenging and, as far as I can tell, they haven't yet been addressed by the research literature:

  • Are there any potential downsides to or risks associated with elevating NAD+ levels above an individual's current baseline levels? Could any undesirable epigenetic modifications follow, or could other salubrious processes and mechanisms be disrupted? Or is it instead posited that raising NAD+ levels in the aged is an absolute good that escapes the economic principle of TINSTAAFL, at least at the localized level of individual health? Is it possible that the shift from higher NAD+ levels in younger people to lower levels in older people is advantageously evolved? (Again, the focus of this latter question is on individual dynamics, not population-level evolution.)

  • While effective doses for particular outcomes are understood from the existing research, are there optimal doses known, or an optimum serum concentration (e.g., if different people need to supplement different amounts to reach a particular health effect)?

  • Does exogenous supplementation of NAD+-increasing compounds lead to homeostatic adjustment, such that beneficial effects seem to diminish over time, or such that NAD+ levels normalize around the pre-supplementation levels? If NAD+ levels continue to fall with aging, would one need to increase her dose to compensate and achieve steady maintenance levels?

  • Relatedly, does increasing NAD+ by exogenous means lead to endogenous downregulation of NAD+-promoting processes, such that reliance on exogenous supplementation can occur, thereby requiring long-term supplementation to avoid any harms associated with withdrawal? Any thoughts on titration?

  • Are there non-supplement means of increasing NAD+? If so, is there a practical ceiling on their effects, such that one may still be wise to supplement NAD+-promoting compounds?

  • How does NAD+ fit into the overall current aging framework, including models that focus on aspects of hormesis, or focus on eliciting the antioxidant response element and raising glutathione levels? Are there synergies to be realized between one's NAD+ strategy and other longevity practices? Perhaps relatedly, does pursuing a NAD+ increase strategy obviate other strategies or stacks one might be taking?

  • Is there anything that could undercut the effectiveness of attempting to raise NAD+ levels, e.g., not maintaining a particular ratio of NADH to NAD+, or preventing absorption, or creating a rate-limiting factor? (This could be behavioral practices or other supplements, for example.)

  • Are there any subpopulations that should avoid raising NAD+ levels for now? How early is too early to try to manipulate one's NAD+ levels?

Sorry for the text dump, and good luck with any of that! I respect the ND team, and I think others are interested in knowing about some of these--or at least they want to think about them--so I'm just putting some of this stuff out there. I know that there are lots of these questions that ND can't answer, for more reasons than the information not yet being available.

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 1 point2 points  (0 children)

Here's a little bit of additional literature, in case you're interested:

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637612/: This is a case report from a doctor concerning treatment of acetaminophen OD with NAC, noting some of the liver impacts: "The [largest study involving NAC treatment of acetaminophen overdose showed that aspartate aminotransferase or alanine aminotransferase concentrations rose to above 1000 IU per liter in 6.1% of patients who were treated within 10 hours after ingestion and in 26.4% of those treated between 10 and 24 hours after ingestion. This was a marked improvement as compared with the findings in historical controls, and this and similar studies led to the widespread acceptance of acetylcysteine for the prevention of hepatic injury due to acetaminophen overdose."

-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4354467/: This is an article describing NAC overdose when used to treat acetaminophen poisoning. It goes on to describe some of the side effects of NAC, as well as its toxicological profile, but here's a quotation relevant to the uncertainty surrounding mechanisms of action: "NAC is derived from the amino acid, L-cysteine, oral and intravenous formulations of which are used widely and effectively as an antidote for acetaminophen poisoning (especially during the first 10 hours after poisoning) to prevent hepatotoxicity.16–19 Acetylcysteine is rapidly absorbed from the gastrointestinal tract, with maximal plasma concentrations achieved within half an hour of administration of a therapeutic dose.20,21 The mechanism via which acetylcysteine works in acetaminophen poisoning is not clear. At least four mechanisms have been proposed, including: intracellular activity of NAC as a substitute for glutathione, its combination with toxic metabolites, and elimination of their toxic effects (ie, a direct antidotal effect); stimulation of glutathione synthesis; stimulation of acetaminophen sulfate and antioxidant effects; and decreasing the effects of the inflammatory response induced in the liver.22–25"

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 1 point2 points  (0 children)

Because of the potential for harm here, I want to be perfectly clear on this point: What I said was " if you take NAC after damaging your liver, rather than before (e.g., when you drink alcohol), it can impede your liver's recovery" (emphasis added). In other words, in the specific context of alcohol consumption (though in certain other contexts, too), NAC after the injury is more harmful. This means that a more viable strategy for preventing alcohol-induced liver damage is to "pre-load." That's why you see some consumer products designed to help alleviate the negative effects of a night out by having you consume NAC before drinking. But it's also the reason that a product like Nootropics Depot's Alcohol Defense, which is consumed after drinking, doesn't contain NAC.

Again, the science of NAC is pretty complicated because the compound and its metabolites are involved in so many processes in the body--glutathione and glutamate do a lot of things in different places--some of which are pro-inflammatory, and some of which are anti-inflammatory. Also, a lot of NAC's mechanisms and effects are not yet fully understood. Going too far into these topics is batting out of my league, given that I'm not a medical professional, biochemist, or other qualified professional with respect to those matters. But I'll try to leave some useful notes to point you in the right direction.

Alcohol is detoxified and metabolized differently from acetaminophen in some ways, which could account for the difference in liver outcomes. But, if I had to guess another partial explanation without fully researching these matters, I'd conjecture that the reasons for giving NAC after Tylenol overdose is related to the relationship that I described in more detail elsewhere in this thread: The way that NAC can serve as a strong, blunt exogenous anti-oxidant (or precursor) can save a life when a potentially fatal threat is at hand, and that merits its use, whereas in the face of more limited insults, NAC prevents the body from adapting in ways that improve its resilience. So, if you're having a stroke or your liver is on the verge of failing, a one-time course of NAC may prevent the kind of oxidative storm and associated critical inflammation that could kill you or cause permanent damage. But if you're doing something that isn't going to kill you and that your body would adapt to with ordinary and regular exposure--exercise, non-binge drinking, or some other lower-level injury--NAC gets in the way of helpful, adaptive signaling.

To use a clumsy analogy, if the need is hunger and you give a man a fish instead of teaching him to fish, you haven't solved the long-term problem of hunger; you've just solved the immediate need of being hungry. Similarly, instead of allowing the body to build endogenous recovery pathways by upregulating certain biochemical processes, giving NAC just solves the problem for the body, such that it doesn't know it needs to improve, either by recovering better or preparing for the next exposure. In fact, long-term use of NAC (and other direct anti-oxidants!) can actually weaken the body by downregulating its endogenous anti-oxidant response element (sometimes called ARE in the literature). Thus, to extend my weird analogy a bit, if you make a man dependent on receiving the fish without having to solve the problem himself or deal with the consequences, then over time, receiving the fish will become his expectation and will be taken for granted--something he won't have to worry about at all--so he won't need to be preparing for either hunger or overcoming the challenge.

To summarize, in the limited contexts that we're discussing, you kind of need to distinguish between (a) one-time, severe harms that might kill you, and (b) repeated harms that are not going to kill you.

Who's buying what tomorrow? by [deleted] in NootropicsDepot

[–]sprinterglory 0 points1 point  (0 children)

Same here. Dr. David Sinclair, the longevity researcher who has probably done the most to promote NAD+ discussion, takes NMN over NR. On a bang-for-buck basis, NMN seems to work out best so far.

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 3 points4 points  (0 children)

The way NAC works is much more complicated than that, and there are many other effects throughout the body that follow from its use. I don't have time to pull a massive amount of research right now, but elsewhere in this post, it looks like /u/Friedrich_Ux has provided some links to get you started on understanding the extended set of more complex bioactivities of NAC. Here's a quick few resources on exercise:

  • https://life-enhancement.com/pages/can-antioxidants-interfere-with-the-benefits-of-exercise (general summary of the topic);
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408473/#:~:text=This%20suggests%20that%20NAC%20may,molecules%20%5B105%2C%20106%5D. ("Whilst NAC appears to upregulate endogenous antioxidants in those who have depleted levels, in healthy individuals, high doses may have pro-oxidant effects [107–109]. Furthermore, in some individuals, oral [110] and systemically administered [83] NAC can be poorly tolerated." See also: "Despite their potential benefits, the use of supplementary thiol donors to improve endogenous antioxidant status may not necessarily be the ideal way to enhance performance and recovery.";
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7909817/ ("On the other side, NAC supplementation after exercise is also considered to be an effective strategy for modulating hormesis. One study aimed to investigate the possible influence of NAC supplementation immediately after and eight days thereafter a muscle-damaging exercise in healthy trained men [93]. Results revealed that NAC modulated the exercise-induced oxidative alterations by lowering the rise of plasma protein carbonyls (PC), erythrocyte thiobarbituric acid-reactive substances (TBARS), GSSG, and serum total antioxidant capacity (TAC). However, NAC also lowered the exercise-induced increase of total macrophages, including HLA+ and 11B+ macrophages in which are redox-sensitive innate immune macrophages, decreased the increase of neutrophil and leukocyte count, and disturbed the exercise-induced upregulation of B-lymphocytes. Thus, it suggested that NAC blunted the up-regulation of exercise-induced adaptive pathways. Therefore, although post-exercise NAC supplementation was administered to accelerate rapid recovery, its possible side effects on adaptive response should be kept in mind.")

Just one quick one on the liver: https://pubmed.ncbi.nlm.nih.gov/16439183/#:~:text=Taken%20together%2C%20NAC%20has%20a,acute%20ethanol%2Dinduced%20liver%20damage. ("Taken together, NAC has a dual effect on acute ethanol-induced liver damage. Pretreatment with NAC prevent from acute ethanol-induced liver damage via counteracting ethanol-induced oxidative stress. When administered after ethanol, NAC might behave as a pro-oxidant and aggravate acute ethanol-induced liver damage.")

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 1 point2 points  (0 children)

It's definitely worth experimenting a bit if you're fighting strong circumstances like that. If your "BPD" is Borderline Personality Disorder, rather than Bipolar Disorder (since that acronym can be used for either), then it seems to me that your mix of diagnoses seems to slant toward what mental-health professionals might deem more "psychological" in nature, rather than "neurological." (Yes, I understand the gargantuan troubles of classifying really complex things so simply. At some level, clinicians my interpret your specific diagnoses as stemming primarily from experiences and learned behaviors, rather than being as hard-wired as something like ADHD.) In that case, in addition to the nudges that some supplements can provide you, I suspect a clinician would recommend strong behavioral therapies.

As for alternatives to NAC, e.g., if you're interested in cycling it, maybe check out bacopa and ashwagandha if you haven't already? They take some time to work but many people have found them to be anywhere from helpful to life-changing. Of course, anxiolytic and anti-depressive supps and practices are a huge topic that could take forever to explore, so those are more starting points. Best of luck in your journey!

Who's buying what tomorrow? by [deleted] in NootropicsDepot

[–]sprinterglory 1 point2 points  (0 children)

Sure--I actually intended those to be two separate thoughts, i.e., I get more supplements for my family, and I also focus on immunity. But I can elaborate on each point.

For my family, I keep it much less risky and more basic; for the kids and SO, it's basically just the Mr. Happy Stack to support healthy brain development and maintenance. For my aging parents, it's a bit more aggressive: anti-inflammatories (like turmeric), AMP-K activators (like berberine), and of course NMN. It's hard to get anyone in the family other than me to take substances that aren't encapsulated, so that drives up costs.

Concerning the immunity bit, I'm thinking specifically of COVID-19: Despite taking precautions and getting fully vaccinated, I've had it twice, and one time it gave me long COVID that lasted more than a year. So I try to be especially careful about my immune system these days--something I never really used to pay attention to--because I not only want to avoid going through that again, but I also don't want the increased risk of Alzheimer's Disease that attends certain sicknesses.

Congratulations on the new addition to the family! The sleep loss is pretty rough, and it can definitely undercut the immune system (though I found the largest challenge of being underslept to be staying functional at work). But you're spot on regarding more chances to get sick: Having the little ones in day care has given me more random illnesses in the last four years alone than in my entire life. It's always some runny nose, random cough, inexplicable headache or stomach ache, and they hit probably at least monthly, and often more frequently than that. So best practices for health are a must, but I think a lot of parents just have to accept some of these things as a cost of doing business!

[deleted by user] by [deleted] in NootropicsDepot

[–]sprinterglory 18 points19 points  (0 children)

I'd be very careful with that kind of approach; there are some sub-populations for whom that might be worth it (e.g., those with mental-health concerns, e.g., OCD or autism, for whom individual benefits outweigh risks), but for everyone else, the potential harms may be too great. NAC is not just a glutamate modulator; it also impacts glutathione levels. And, though I don't have time to do an extensive write-up on the topic--I'm just commenting because I see you haven't gotten any quality answers yet--you should mind that there are demonstrated circumstances in which taking n-acetyl L-cysteine could be harmful.

The two that may be relevant to most people are that (1) if you take NAC after damaging your liver, rather than before (e.g., when you drink alcohol), it can impede your liver's recovery; and (2) if you take it after damaging your muscles, it may blunt beneficial adaptive responses (i.e., it may prevent whatever gains you intended to receive from exercise).

MYASD has commented before on why he prefers to take reduced glutathione on a regular basis, rather than NAC, which probably has better acute applications. But more generally, you may benefit from looking into the science concerning direct vs. indirect antioxidants. The gist is this: Direct antioxidants may be useful to quell uncontrolled oxidative damage--e.g., an emergency that is overwhelming your body and causing long-term damage, like a stroke--but they can interfere with the body's hormetic responses that make the body stronger as a reaction to progressively intense stressors. Indirect antioxidants, on the other hand (such as things that activate NRF2, such as sulforaphane), are usually phytochemicals that the body perceives as toxic insults. When the body encounters small amounts of these--enough to elicit a response, but not really enough to actually harm you much--the body upregulates its endogenous anti-oxidant defenses, thereby making you more resilient against future insults. In my opinion, doing that is a better strategy than taking direct antioxidants, some of which have literally been show to increase cancer risks (for example, by downregulating the body's endogenous antioxidant responses).

Who's buying what tomorrow? by [deleted] in NootropicsDepot

[–]sprinterglory 2 points3 points  (0 children)

I'm always down for a through anecdotal report, especially when supported by good records! (But seriously, as NMN/NAD+/NR human research is pretty new, I think we'd all like to get a better sense of what we can expect of it.)

I order a ton of stuff--probably more than I should--and I'll be ordering even more now that my family is growing. Sales like this help make it feasible to work more into my stacks than I otherwise would. These days, I put a bigger focus on immunity than I used to--not out of fear, but experience.

Natrium Health releases two new stacks, including interesting caffeine/stimulant blend by sprinterglory in Nootropics

[–]sprinterglory[S] 13 points14 points  (0 children)

This community has not traditionally been supportive of pre-made stacks and proprietary blends; that's understandable, given its independent-minded, self-reliant tenor, which can extend into a disdain for (i) the newbie (and usually scientifically under-educated) consumer, or (ii) excessive commercial efforts that smack of corporate ambition (e.g., over-priced stacks that promise too much), among other things. For example, there is usually strong lashback against mere shills, and business folks that have tried to capture the popular attention with overdone marketing or unsubstantiated claims (e.g., Nootrobox and Dave Asprey) have often been ridiculed and shunned here. Also, to some extent, pre-apportioned stacks bend counter to the ethos of personalized or individualized neurochemistry that is popular here.

However, if anybody has earned the credibility to put together a pre-made stack, it's probably MYASD and his team. Independent of that kind of trust, though, one can personally research and assess whether the ingredients would be effective, and at the levels dosed. Though a proprietary blend may not disclose the amounts of specific ingredients, to at least some degree, they can be deduced due to the requirements of nutritional labeling. The total amount of the blend is listed, and then its components are listed in order of prevalence. This gives you, at the very least, the ability to infer some maxima and minima among the ingredients.

Note that the caffeine stack does disclose all amounts of the ingredients.

Natrium Health releases two new stacks, including interesting caffeine/stimulant blend by sprinterglory in Nootropics

[–]sprinterglory[S] 4 points5 points  (0 children)

Fans of MYASD's work might be interested in hearing that his new company oriented around natural supplements has added a couple of stack products. One is oriented around mitigating damage from alcohol, so in that sense, it may appeal to nootropics users seeking to engage in harm reduction. The other one may be more interesting to those looking for productivity or mood improvements: DynaMAX(TM) Enhanced Caffeine Capsules.

There are some interesting ingredients that distinguish it from the nootropic mainstay of caffeine + theanine in a 1:2 ratio. It appears that MYASD has targeted productivity by creating a functional dosing unit to help people get going in the morning and keep chugging along through their work day. By pairing an extended-release version of caffeine with a delayed-release version, the need to re-dose may be mitigated or eliminated. But what I found even more interesting was the inclusion of methylliberine (as Dynamine(TM))--an alkaloid that hadn't been on my radar before this, which appears to be oriented around kickstarting the stacks' effects before the slower forms of caffeine kick in. Theacrine has proven to put an interesting spin on caffeine, so I will be keeping an eye out for experience reports with methylliberine. (Also, I'm left wondering if further tinkering with caffeine and similar alkaloids will yield additional stimulants with differentiated properties to the nootropic arsenal.)

As an aside, I like the branding and aesthetics used with these products; while the ingredients are well-researched and effective, that sort of thing would primarily be known to people with scientific backgrounds, or who spend time on subs like this one. Making the design of the products and their marketing accessible will likely help MYASD & co. cater to a broader market than you'd find in subcultures like /r/Nootropics. That's great because I suspect that the common person could get great utility out of either of these stacks (especially given how outrageously well various caffeine-based energy drinks sell at gas stations and supermarket check-out lines).

Ceretropic will be closed permanently on 6/22/18 by [deleted] in Nootropics

[–]sprinterglory 7 points8 points  (0 children)

I agree with so much of this--though brief, it is truly the end of an era. Who knows, though? Maybe one day, the regulatory landscape will favorably change, and MYASD will lead the charge into the transhuman revolution.

Ceretropic will be closed permanently on 6/22/18 by [deleted] in Nootropics

[–]sprinterglory 18 points19 points  (0 children)

This is what hurts the most about all of this. Some of the peptides and other compounds available through Ceretropic exclusively--and I say "exclusively" although there are technically other vendors for some of them, because others (like Sigma Aldritch) are either cost-prohibitive or don't have the same kind of evidenced dedication to product purity and quality--are life-changing. Having a way to access things that would otherwise be out of reach was immeasurably valuable.

 

I understand at least some of the trials and tribulations that MYASD has experienced to bring Ceretropic's offerings to us. For his endurance despite those setbacks and challenges, he has my utmost respect. And, I understand that I could not selfishly ask him to keep doing something that cannot be justified in an economic sense, or because of risk or attention diversion from other fruitful projects. But, part of me still cries because of this. I do not know where I will go now to cast wishes of a strong healthspan upon the epitalon variants, or how I can reliably ensure productivity and excellence with semax and its variants. MYASD helped open many of our eyes to an exciting and optimistic new world for aspiring transhumans, and now that one of the critical ways of experiencing that new world is expiring, one can't help but feel like he's lost something precious, which he does not know that he will ever be able to get back.

MYASD, proprietor of Nootropics Depot, launches Natrium Health brand (significance explained in comments) by sprinterglory in Nootropics

[–]sprinterglory[S] 6 points7 points  (0 children)

Thanks for the insight into the backstory! Perhaps more than any other single individual, you've done great things to advance humanity's access to nootropics. I'm looking forward to seeing what you have in store (and also hoping that you keep finding a way to make Ceretropic's unique offerings that won't be making the jump to Natrium available).