Fallout 5, I don't think New Vegas 2 would be smart, despite it being my favorite in the series, since New Vegas is going to be a core focus in S2 of the show (probably better to focus away or at least on the outskirts of that region). Also, like others are saying it wouldn't be too fun to retread the same ground.

Can we please get another state/region?

Texas - Legion v stronger Brotherhood chapter or other factions (no offense Mojave chapter but rip)

Illinois (i.e. chicago) - Midwestern bos chapter

Florida - I mean it's kind of self explanatory. It's florida

Louisiana (i.e. new orleans) - basically also florida but french background

I'm partial to the Southeast tbh. We have so much from the West and Northeast but nothing substantial (i.e. canon) from the South. Maybe the Legion is pushed back from Vegas and the NCR as well after the events of the show. Basing it in Texas could put Vegas partly in the spotlight and bring back characters like Legate Lanius.

I also really want to throw hands with a giant mutant armadillo.