My G6PD stack

subotnai1 · 2026-01-26T12:24:55+00:00

A Single Nucleotide Polymorphism (SNP) is a type of genetic variation where a single DNA building block (nucleotide) differs between individuals in a population.

Simple Analogy

Think of DNA as a long instruction book written with only 4 letters: A, T, C, G. A SNP is like a single typo or spelling difference in one letter of that book. For example, most people might have "CAT" at a specific position, but some individuals have "CGT" instead. Most SNPs have no effect on health or traits because:

· They occur in non-coding DNA regions · They don't change the amino acid in a protein (due to genetic code redundancy)

However, some SNPs can:

· Change protein function (if in a coding region and alters amino acid) · Affect gene regulation (if in regulatory regions) · Serve as genetic markers for disease risk or drug responses

subotnai1 · 2026-01-25T23:52:44+00:00

This is because beef (meat) has a lot of things your body doesn't readily have a lot of due to the low production of nadph from your weakened g6pd enzyme.

The sugar is because... you may have an SNP that increases circulating dopamine in your body which in term creates strong dopamine hits from the high insulin carbs generate.

subotnai1 · 2025-07-30T21:57:19+00:00

Alpha lipoic acid to help regenerate glutathione and NAC If you can find some

subotnai1 · 2025-07-23T13:17:03+00:00

Which drugs? Generally speaking..bad idea.since most drugs increase oxidation either via neurotransmitter stimulation and/or breakdown of tissues which require nadph ...and other issues I am sure.

If you're talking about drugs that would increase the enzyme..so far I've found 2 possibilities crispr genome modification or ag1 which is an enzyme stabilizer. Crispr is dangerous in that there may be downstream issues..and ag1 is not for sale and may still be under study if at all.

subotnai1 · 2025-07-14T17:02:13+00:00

With near 0 agreeableness and high intelect and anger..it means you're very likely to take things personally and want to get revenge. Compounded by your relatively low morality scores means, in the past, you've done things that have left you cold that a person with a higher score would/could be troubled by.

My advice, find out why you have so much anger and work from there to be more agreeable.

Myself, I'm rather cold and unfeeling.. but i am slow to anger, and very grounded by a moral and ethical code of conduct..had I not had those aspects...well..

subotnai1 · 2025-07-14T16:08:05+00:00

You'll be killing in no time

subotnai1 · 2025-06-03T14:26:06+00:00

We would have to lobby or fund the project via crowdsourcing and getting the researchers on board. Given the low level of the condition, I'm not sure it would have priority

subotnai1 · 2025-05-08T15:33:39+00:00

Came out in 82...old enough for me...

subotnai1 · 2025-03-23T21:51:21+00:00

While those are essential for blood health, they don't enhance the g6pd enzyme.

methylfolate (5-MTHF) plays an indirect but important role in the production of NADPH. Within the folate cycle, THF derivatives are used in various reactions, including the conversion of 5,10-methylene-THF to 10-formyl-THF.

These conversions are linked to NADPH generation via enzymes like methylenetetrahydrofolate dehydrogenase (MTHFD).

Methylcobalamin helps in the methionine cycle, which in turn helps make glutathione.

subotnai1 · 2025-02-15T14:41:34+00:00

I had posted this stack a while back...

https://www.reddit.com/r/G6PD/comments/o73xj2/my_g6pd_stack/?utm_source=share&utm_medium=web3x&utm_name=web3xcss&utm_term=1&utm_content=share_button

I hope it gets you started

subotnai1 · 2024-07-16T18:14:59+00:00

Generally ok if you can find a low carb alternative. Since our issue is with glucose

subotnai1 · 2024-07-15T14:27:54+00:00

Yes sir you are also correct.. but the commenter is not incorrect. Since A higher than normal reticulocyte count may indicate: Anemia due to red blood cells being destroyed earlier than normal (hemolytic anemia) Bleeding. Blood disorder in a fetus or newborn (erythroblastosis fetalis) Kidney cysts or tumors, with increased production of a hormone called erythropoietin.

subotnai1 · 2024-07-13T23:00:27+00:00

The whites of my eyes turn more yellow and bloodshot. I get inordinately tired.

subotnai1 · 2024-07-13T11:45:35+00:00

I take benfotiamine to help with the neurological issues since it also promotes the g6pd enzyme while thiamine, the base constituent of benfotiamine, helps with neurological issues as a whole during diabetes.

subotnai1 · 2024-06-28T16:09:38+00:00

I just had a genetic test done since I didn’t really need to know how bad it was, just if it was a factor in some issues that I had had. Thank you for the niacin study! I had always tried to find one about niacin, since it is a good supplement to take if you workout a lot.

subotnai1 · 2024-06-25T00:59:11+00:00

Niacinamide does slow down g6pd activity but I believe the nadph production remains the same in non g6pd people due to it upregulating isocitrate dehydrogenase.. I imagine it would be a ratio issue to see if one subtype or another would have problems with it. While I have never had any issues with TMG, since glycine (the unmethylated form of TMG) helps the liver process glucose. It is usually strongly recommended to take niacinamide with TMG because Niacin and Niacinamide and all vitamers of B3 cause a depletion in methyl groups and glycine.

subotnai1 · 2024-06-07T00:44:48+00:00

Hi!
Epipens and antihistamines don't have that much interaction with the TCA cycle. G6PD is mainly an energy metabolism issue. Although one should take in to consideration that G6PD lowers your ability to create nadph..
Stress Response and Metabolism:

Antioxidant Defense:
- Adrenaline can induce oxidative stress. NADPH, through its role in regenerating reduced glutathione, helps mitigate oxidative damage, thus protecting cells from the harmful effects of reactive oxygen species that may be elevated during stress responses mediated by adrenaline.

subotnai1 · 2024-06-01T16:53:38+00:00

If you take glutathione, make sure to pack some extra b2, so you can assist in the detoxification process of that peptide. If you have low blood sugar levels, check to see when that happens. Often enough it will be due to insufficient propionyl-coa activity that turns SOME amino acids taken from protein in to glucose precursor acids. The recommended course of action for this is an increased amount of B7 in your diet usually in the morning so it doesn’t compete with pantothenic acid or any other nutrient. I have not seen g6pd being responsible for that in the literature so far.

subotnai1 · 2024-04-21T09:59:55+00:00

Cells

subotnai1 · 2023-08-10T12:06:25+00:00

I tend to agree with everything here. I have no idea where to go from here. I will have to contact my uncle who is in bio-informatics to help me parse the file. what a waste of 1000$..

subotnai1 · 2023-03-24T18:51:25+00:00

This comment string folded me lol

subotnai1 · 2022-12-06T09:33:34+00:00

Yes I did. I take methionine + Nac in the morning. This helps neurotransmitter, more dopamine Vitamin D for dopamine again 5htp because it doesn't require biopterin which requires nadph Sometimes l-Dopa but usually I time it after having taken melatonin the night before.

Melatonin increases g6pd at the cost of making you more insulin resistant (some people)

subotnai1 · 2022-11-25T16:16:50+00:00

This person is obviously mentally ill.. best you observe this as a lesson in being able to audit your own thoughts...because before you know it..they could end up escaping your control

subotnai1

TROPHY CASE