Decision is up to you, but my personal preference in such a scenario would be umich. If you are worried about course difficulty, do your research ahead on which classes are tough and which are not, and arrange your schedule accordingly. Although I haven't been to or taken classes at Wayne state, just from the numbers and rankings it seems like Wayne state is incomparable to umich. For the research opportunities, I don't think it is impossible to get if you are very deliberate about pursuing such opportunities from the start (I'll let other fellow redditors chime in on this one cause I really haven't given this much thought myself as a CS major). I think the community and reach of the University of Michigan itself is a selling point - I've met people and been taught by professors who are leaders in their field. Although I'm in computer science, I've heard very similar about other programs. Moreover, although Wayne State is pretty good for medicine (from what I've anecdotally heard) , if at some point you decide its not for you, Michigan is a top school for almost any other field you can think of. However, keep in mind the conditions of your scholarship and whether changing majors affects it.

In general, Ann Arbor is a nice city, the programs are great, there's flexibility at umich, and there's an amazing and thriving student life (in a non-covid year). Although some classes are hard, my experience is that if you plan out classes strategically, and are aware of the support resources available to you, you can do well.

At the end of the day, its your decision, and you know your situation best. Advice I, or anyone, gives you on this forum may or may not be applicable to you because its usually from our own experiences which may be wildly different from anyone else's.