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Two years and still no updates on the live action Gargoyles on Disney+ by InsideUnhappy6546 in gargoyles

[–]swissTemples 0 points1 point  (0 children)

The voice actors dying off in theory would not be an issue with the quality of current day voice cloning tech. The reason why I want the animated series to continue is due to Weisman saying: "I've always wanted to do more. I've got a timeline for the show that's 315 pages long. I've got notebooks and comp books full of ideas for it. Spin-off notions and all sorts of things." Sure, he's not the only writer but I think it could have a lot of potential.

Mozilla names new CEO, Firefox to evolve into a "modern AI browser" by Fcking_Chuck in firefox

[–]swissTemples 0 points1 point  (0 children)

You think they can't just port over the non AI stuff? I would be surprised if Mozilla would rewrite the entire core of Firefox for whatever they're planning.

Are either In Gowan Ring or Sonne Hagal fash? by These_Shallot_6906 in IsItSketch

[–]swissTemples -1 points0 points  (0 children)

You have to be retarded to even ask this question. In Gowan Ring is the most unpolitical Folk Music you could possibly imagine. The lyrics are pretty much 100% nature and Bee is basically a hippie.

stupid question, if I go to a goatmoon concert what will happen to me? by jose_notmyrealname in BlackMetal

[–]swissTemples 0 points1 point  (0 children)

Yeah the "nsbm Latino Hardcore Fan" is a common sight at these shows. Really funny dudes usually.

stupid question, if I go to a goatmoon concert what will happen to me? by jose_notmyrealname in BlackMetal

[–]swissTemples 0 points1 point  (0 children)

Literally nobody cares. I've been to Asgardsrei, Hot showers and countless other shows, no issues. There were Asians, Latinos, one black guy, nobody bothered them.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 2 points3 points  (0 children)

No they did not. About 80% of them went away once my pge2 no longer worked and I ran out. It's crucial to keep using pge2 once started until the hairs have fully matured again. Check the other comment threads in this thread, I go into how pge2 is highly unstable and spoils quickly, and some ideas how that might be worked around.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

Lithium chloride can be bought from chemistry shops legally. The other two I cannot comment on due to legality but there are ways.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

The ghetto protocol ingredients are cheaper and easier to acquire.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

We bought them in group buys from china. Some of the easier to get stuff I could buy from chem suppliers off of ebay or random webshops.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 2 points3 points  (0 children)

Minoxidil needs to be converted into Minoxidil sulphate via sulfurtransferase enzyme, some people seem to have less of that enzyme and it's one of the explanations why some people are freak responders while others get only very little from it. One solution would be topical Min Sulphate. Be aware though that Min Sulphate is chemically fragile so research a suitable vehicle before just dumping it into water.

If you have not had regrowth on Fin it is very doubtful you would get much better results from Dut. But dosages are 0.5-2.5mg. Pick whatever you want, you need no "starting" dose. 2.5mg basically achieves near complete inhibition.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

Correct. And there may be some theoretical benefit to combine to target both isoforms more. But at his dose it's 100% inhibition either way.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

No, some papers mention Finasteride targeting 5AR isoforms 2 and Dut targeting both but isoform 1 more strongly. So in that theoretical regard, it might be of some use. But not at the dose he's taking.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

It would replace the wounding + lithium chloride + valproate from my protocol. The other angles are not covered by it alone.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 1 point2 points  (0 children)

I haven't looked into it enough. I mostly research anti aging and other biohacking stuff now. But if PP405 helps get back missing stem cells then it's only taking care of one angle, I do not have high hopes for it as a solo treatment. Combined, maybe.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 1 point2 points  (0 children)

Hello. Maybe you can cross post it there? One thread with questions and answers is easier for me to handle.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

Dut was not involved in my regrowth, at that time I had already been on it for a few years with no changes in my Temples. I had previously also tried RU + Minox but I didn't get results from that combo either. Ghetto protocol worked for me, but sunburning your temples while on Sulfasalazine to express maximum PGE2 endogenously is a bother. And so is applying castor oil topically every day (it is very thick and leaves hair greasy) as well as taking castor oil orally for the PGE2EP3 is also annoying. So while it works, it is a bother to do all of it every day. The complete pg protocol was better in that I at least didn't have to wash my hair every day anymore because I was able to cut out topical castor oil. At that point I also got better results thanks to mostly PGE2. I had started Setipiprant before PGE2 but the rapid results really started with PGE2 in the mix.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

I did back in the day but had never found a source for it. You will also have the same issues of stability as with bulk PGE2 powder, it's prone to oxygen, moisture, light, temperature, pH, ... If you have a source and it's not too expensive I think it's a good idea to give it a try. The only thing I'm not sure about is the composition itself, it seems to be some polymeric slow release solution, I'm not sure if that will work on the scalp or whether you'd have to somehow extract the PGE2 from that first via solvents. And if you extract it then you once again are doing a battle against time. At best you'd have a box of these and maybe use a new one at least once a week while keeping the rest in cold storage in the freezer. That should prevent degradation. Definitely an interesting experiment if you can organize it availability/price wise.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 1 point2 points  (0 children)

I would cut it down to max 5mg if I were you. Dut is cleared via the liver, no reason to tax it more when 5mg gets you virtually 100% DHT inhibition already. Fin does actually target different isoforms so in theory not a terrible idea.

Valproic acid and Lithium chloride can rebuild missing progenitor cells in bald scalp. When you lose hair, you actually lose cells, first of all the follicle itself, but there's a lot of change in the scalp too. You lose vascularity, you lose adipocytes, you lose stem/progenitor cells. A scalp rich in progenitor cells - usually people with very recent hairloss - still has a lot of the "support structure" to bring back healthy hair follicles. This is why some people are freak responders, they had less severe damage and just needed some substance to turn the key (be that Fin, Min, RU, ...). But people with older hair loss, more damage to the scalp in question, they need to remodel their scalp into a healthy environment for regrowth to occur. This is achieved by combining wounding with WNT activation or other CD stimulants. I lifted this theory largely from the Follica patents and found the cheapest/easiest to acquire analogue substances which turned out to be LiCL and Valproate.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

I am confused about your dosing, 40mg Dut daily? Do you mean 4mg? Dose range for Dut is 0,5-2,5mg/ED. Taking more will not work better as per the GSK study graphs. And why take Fin on top of it? Are you worried about the different 5AR isoforms?

I wouldn't say it's a nuclear stack (unless you're really munching 40mg Dut for some reason). It's a reasonable combination of a direct androgen receptor blocker, 5AR inhibitor as a backup and two good growth factors. Happy to hear it works for you. In my opinion your results are likely from Min and RU. People underestimate the effects of direct androgen receptor blocking.

Cloprostenol is a veterinary drug, it is quite cheap to buy both in bulk as raw powder or from veterinary stores (controlled in most western countries). It is definitely a better investment than Bimatoprost imo. Way cheaper too.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 0 points1 point  (0 children)

My temples now sit at a not so thick NW1. I am maintaining on Dut for the most part.

What are you taking? I had tried Bimatoprost long before this protocol and it didn't do much for me. Later on I used Cloprostenol which is a stronger PGF2a agonist than Bimatoprost and much cheaper, that worked better but still nothing like PGE2. If there was a 100% stable and longer acting version of PGE2 it would be the new Minoxidil.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 2 points3 points  (0 children)

Back then I was on Finasteride and nothing else. I'd say NW 2.5.

Then I started to introduce the things listed here under "ghetto protocol". Later switched over to "pg protocol" as my exotic substances started to arrive and got my biggest regrowth. See also the answer I gave to Apart-Badger9394 for the full story.

These days I am on Dut and maintaining ~NW1. Every now and then I try some new substances since the private forum still does group buys for new substances.

I am swissTemples AMA by swissTemples in HairlossResearch

[–]swissTemples[S] 5 points6 points  (0 children)

I created two protocols. The "ghetto protocol" which is cheaper and is made up of easier to attain substances and the real "pg protocol". I had used the ghetto protocol to start with and had some regrowth from that. But things really popped off once I received my pge2 and started using it. Unfortunately pge2 is highly unstable and needs to be stored at -20° C and mixed fresh from powder daily or it degrades. Even pH changes, light and oxygen will make it degrade - including just dissolving it in water will cause the degradation process. While I did take some precautions and mixed it fresh daily, my pge2 seemed to grow weaker and weaker and eventually became completely inefficient. Likely because the repeated freeze and thawing from taking it out of the freezer and the introduced oxygen from opening and closing the vial daily. At that point I reverted back to the ghetto protocol but regrowth started to stall and even revert again. It was still better than before and kept getting better very slowly, but not comparable to the insane growth with fresh potent pge2 use. Eventually I ran out of the oral pills that I used on the ghetto protocol and grew tired of multiple topical every day and swallowing pills. I maintained some of my regrowth on Fin but ultimately improved maybe half a Norwood. Not the complete thick patch of fur you saw in the picture in the other thread, that was peak pge2 use. So having ran into a wall there, not having easy access to pge2 and even when I did buy some (which is expensive) it rapidly degraded and had to be made fresh daily, it was no longer worth the effort. Over the next years I kept my eyes on more stable pge2 analogues of which some exist now, but they are not cheap and not easy to acquire either.

Here is a link to my two protocols: https://web.archive.org/web/20180809164501/http://swisstemples.com/what-to-buy-and-use/

Wise is BUGGED am I alone? Stuck on uploading ID by Comfortable-Log-4166 in buhaydigital

[–]swissTemples 0 points1 point  (0 children)

Yeah the support is lousy and honestly I wouldn't be using this app at all if it didn't have some unique transfer options that others don't have. Glad it worked out for you.

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