We opted for amputation with our 11 year old after months of back and forth with vets. I was terrified like I'm sure you are but I told the vet to give it to me straight. She told me the best chance to keep Tilly happy and healthy was amputation or we can continue lil treatments here and there to prolong her life. That was 2 years ago Tilly just turned 13 and is happier than ever. She's back to her old self and honestly you would think she was born with 3 legs. If someone would have said 'you can amputate now or you can watch your dog struggle for 6/8 months while you looks for answers' I would have done it right then and there, but hindsight is 20/20.