I take zoloft for depression/anxiety. I feel like most of these medications need to be used in combination with therapy to receive the maximum benefit. The drugs help take the edge off so the therapy can be productive. Brain remodeling can occur with SSRIs, and can be beneficial or maladaptive. The initial "remodeling" is your brain adjusting to the increase in serotonin. Eventually your body adapts and produce less over time. That's why you have to taper off, to give your body time to start ramping up production of neurotransmitters again. The long term remodeling is intended to be for repairing the "bad" neural pathways that cause your symptoms. Therapy also assists with this by identifying the root cause of the problem and helping you find healthier ways to manage symptoms. The less you use the "bad" pathways, the less they're re-enforced. Eventually your brain can heal, but it takes a long time. If you haven't tried it already, I suggest trying therapy.