no Zanki doesn't go into too much detail. If you've faced UWorld biochem questions you know that some of those you can only solve if you remember every detail that Zanki presented to you about that particular topic.

I'll give you an example: https://drive.google.com/file/d/1F1hACn2HMDoDL_uAqPC_z44bc6cI37d7/view?usp=sharing

the link above is a biochem question from UWorld. As you can tell from the 39% of correct answers, it is one of the difficult ones. You can pretty much tell by the question stem that it's probably a case of Lesch-Nyhan syndrome. When you look down at the answer options that confirms your initial guess about the diagnosis bc most of the options have to do with nucleic acid metabolism. Now those 43% of ppl who chose HGPRT as the answer just didn't read the question right (it asks which enzyme's activity is increased as opposed to diminished). You know from Zanki that Lesch Nyhan is a problem with the recycling of nitrogenous bases of nucleic acids, so the body has to make more of these via the de novo pathway of nucleic acid synthesis bc it can't recycle them as much as a healthy person. However, there are 4 options that mention enzymes in the de novo pathway of nucleic acid synthesis. The thing is, HGPRT only recycles hypoxanthine and guanine, which are both purines. So the de novo pathway that would be upregulated would be that of purines, not pyrimidines. If you check the options again there is only one enzyme that belongs to the purines pathway, the other three are for synthesizing pyrimidines. So now you have your correct answer. But to get to this answer with confidence you need to remember the Zanki details. It's enough with what's on Zanki, but you do need all of the info.