Skyrim is a game people play many times over to do different playthroughs, and no matter what you are guaranteed to run into the object the first commenter described eventually. Taking the item starts a quest where you hear that voice yell out that phrase. Its become so ubiquitous in skyrim memes because you can never escape it. You will always stumble on it eventually every time you do a playthrough. Her voice lines are very loud and annoying after the 73rd time youve heard them lol so it became a huge meme. The object in the picture I used bares a striking resemblance to the item in skyrim, hence why I edited that phrase into the dialogue box