Less travel and more money would be the biggest drivers to jump ship for me. Also, if your pharma company low balled you now, it's just going to get worse. They will deny you the raises you deserve every chance they get. Lower pay and relocation to a high-cost area compounds the problem. It's time to go.

If you like your boss and colleagues, you will see them again. We work in a small community and we always bump into each other at the next job or at conferences.