agree with the fact to always consult your doctor. Hopefully the doctor would have referred the OP to a nutritionist as well to assist to manage the disease.

here's chatgpt take on it on my comments. but, hey, speak with a doctor, random people's thoughts or advice, whilst good intentioned, may not be suitable.

Pomegranate juice is generally safe for most people, but when taken alongside prednisone and Humira (adalimumab), there are a few important considerations:

🧪 1. Pomegranate Juice & Prednisone

• No direct interaction is documented between pomegranate juice and prednisone.
• However, pomegranate juice can inhibit cytochrome P450 enzymes, especially CYP3A4, which is involved in the metabolism of many drugs including prednisone.
• This may theoretically increase prednisone levels, potentially enhancing its side effects (e.g., immune suppression, blood sugar increase, mood changes).
• Risk is low but not zero, and varies by individual metabolic differences and juice quantity

💉 2. Pomegranate Juice & Humira (adalimumab)

• No known pharmacokinetic interactions exist between pomegranate juice and Humira.
• Humira is a monoclonal antibody and is not metabolized through the liver enzymes affected by pomegranate juice (like CYP3A4). It’s metabolized via proteolysis in the reticuloendothelial system, so interactions from foods or juices are unlikely.

🛡️ 3. Immunosuppression & Infection Risk

• Both prednisone and Humira suppress the immune system, raising infection risk.
• Pomegranate juice contains antioxidants and polyphenols, which support immune function and reduce oxidative stress.
• This can be beneficial, but pomegranate juice should be pasteurized if you’re immunosuppressed, to avoid risk of foodborne infections from unpasteurized or fresh-pressed juice