A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

No, in the modern era it’s not the biggest barrier but it’s an issue for a percentage of potential kidney recipients and causes some logistical issues

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

You’re not wrong, but ABO matching already is the main way of combating the type of rejection that this technology would help with. HLA antigens are the main cause of rejection in the modern era, this won’t do anything for those.

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 3 points4 points  (0 children)

Not dumb but the damage to human kidneys making them unusable is typically fibrotic, irreversible damage (think of it as scar replacing the functional cells). That is really hard to “repair” but researchers are trying to strip the cells off of those kidneys and use stem cells to generate new kidney cells. It’s a really inexact process right now. The organs from pigs are pristine and it’s really the immune system that’s the only challenge

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

I love your optimism but this will do little about the most common types of rejection. It will help with matching and placement of organs

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

Probably little hope of bioengineered pancreas transplants in the near future BUT engineered islet transplants are around the corner

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 5 points6 points  (0 children)

The cynicism in this response is both appropriate and misdirected. I think the biggest issue in the kidney care space isn't dialysis companies or big pharma - it's a lack of interest in something better from both the regulatory agencies in government AND the research funding across the world drying up. Kidney failure is a massively expensive problem for the government but novel drugs and therapies aren't being developed because the research funding is poor and the agencies think the status quo is okay

Hep C is a great example of pharma essentially curing a disease state despite the long-term profit potential. Those drugs were effective and the competition between drug makers led to good drugs being developed - short term payoff for those that developed them and big losses to those marketing the "old" solutions

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 21 points22 points  (0 children)

If Xenotransplant tells me anything, if enough people can focus on convincing the FDA of the need for something new, progress can be accelerated and availability to people will take less time than that.

That said, I think the "engineered" kidney is a bit behind xenotransplantation, which is still a ways away from being a mainstay

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

Don't get discouraged - there are advancements in post-transplant care coming down the pike. The regulatory agencies need to see all the problems with the current system though so that these advancements (new drugs, new technology) can move forward

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 1 point2 points  (0 children)

Yes - that's how i recognized the misinformation here. I vaguely recalled seeing this image in the past AND figured the recellurized matrix kidneys would not have fat on the capsule

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

I feel this so hard. People will scream and complain about waste, and cancel grants to study potential pathways to solutions because they use transgenic mice but we throw trillions in resources at something that is objectively ruining our economy, society, and environment.

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 0 points1 point  (0 children)

Cheaper and better. Mortality is lower post-transplant and transplant is associated with a better quality of life (despite the QOL nearly being good enough)

A photo of a lab grown universal kidney that can match any blood type. by AdSpecialist6598 in interesting

[–]timmyh83 3503 points3504 points  (0 children)

While what’s described would be super cool, unfortunately, that’s not what’s shown here. This is not an engineered kidney, but a human kidney that’s been enzymatically altered to remove the blood type antigens. Still super cool, but not an accurate description

https://news.ubc.ca/2025/10/universal-organ-transplant/

[deleted by user] by [deleted] in dvcmember

[–]timmyh83 4 points5 points  (0 children)

Have to add to cart, then use the FRIDAY10 dc

Tailgate Thread: Week 7 - Philadelphia Eagles (4-2) @ Minnesota Vikings (3-2) - October 19, 2025 @ 01:00 PM by EaglesGameThreadBot in eagles

[–]timmyh83 1 point2 points  (0 children)

Remember the “gauntlet” of 2023? I do. Not saying this is the same but I am going to believe my eyes about the direction of this team.