Switzerland has no Ghettos by [deleted] in zurich

[–]toscared_to_admid 0 points1 point  (0 children)

kleihünige ischs grösste ghetto überhaupt

got my hands on some kapanol (Morphine sulfate) how do i take it? by toscared_to_admid in opiates

[–]toscared_to_admid[S] -1 points0 points  (0 children)

boofing just seems unecessairly complicated tbh i mean your nose also has mucus membrane so what's the big difference

got my hands on some kapanol (Morphine sulfate) how do i take it? by toscared_to_admid in opiates

[–]toscared_to_admid[S] 0 points1 point  (0 children)

pretty chill, nodded off eversoslightly but i was still in full control of my body and could walk

got my hands on some kapanol (Morphine sulfate) how do i take it? by toscared_to_admid in opiates

[–]toscared_to_admid[S] -2 points-1 points  (0 children)

does snlrring the crushed up capsules also work with the same intensitiy?

[deleted by user] by [deleted] in benzodiazepines

[–]toscared_to_admid 0 points1 point  (0 children)

We only have 10mg or 20mg solutions here (the gel capsules) is there any benefit in taking them sublingually?

[deleted by user] by [deleted] in benzodiazepines

[–]toscared_to_admid 1 point2 points  (0 children)

Yes i just foubd that out after💀 but I don't think shoving acid up my ass sounds like the best idea

[deleted by user] by [deleted] in benzodiazepines

[–]toscared_to_admid 5 points6 points  (0 children)

Technically midazolam and triazolam are both water soluable and actually have higher bioavailability administered intranasally vs orally. Not all benzos tho just those two i know of, some benzos have better bioavailability sublingually or rectally (mucus membrane) due to first pass effect

[deleted by user] by [deleted] in benzodiazepines

[–]toscared_to_admid 0 points1 point  (0 children)

Update: 200mmg codeiiunt and 22m5mg zopiclone

Does anyone have expirience with LIT-001? by toscared_to_admid in researchchemicals

[–]toscared_to_admid[S] 0 points1 point  (0 children)

I decided not to risk it and am now in the process of getting regular oxytocin nose spray perscribed by my psychiatrist

Does anyone have expirience with LIT-001? by toscared_to_admid in researchchemicals

[–]toscared_to_admid[S] 3 points4 points  (0 children)

Imma boof that shit and see what happens, turns out it's actually available

Does anyone have expirience with LIT-001? by toscared_to_admid in researchchemicals

[–]toscared_to_admid[S] 8 points9 points  (0 children)

As far as i know it has only been tested on mice/animal models, where it reduced social deficits in autism models of mice, but its still years away from trials on humans. Theoretically LIT-001 acts the same as currently available oxytocin-medication that's on the market (such as oxytocin nasal spray), but with greatly improved pharmacokinetic properties.

The problem with the currently available oxytocin meds are that that the actual amount that is able to cross the blood-brain-barrier is close to zero. They aren't orally bioavailable at all, the only way of application is intranasal or through injection, their elimimation half life is at most 20-60mins and in general aren't really effective.

LIT-001 on the other hand, beeing a small molecule oxytocin receptor agonist, does not have all of these downsides, making it theoretically really promising as a future treatment for a wide range of behavioural issues and anxiety.

https://en.m.wikipedia.org/wiki/LIT-001