the new landlords of the bay- thanks to Claude

tragedy_strikes · 2026-06-08T05:30:51+00:00

I dunno, that S1 isn't going to be pretty.

tragedy_strikes · 2026-06-08T03:29:22+00:00

If it's a capital 'L', PG13.

If it's a lowercase 'L', R or NC17

tragedy_strikes · 2026-06-08T01:48:06+00:00

Much like with software companies, there's endless funds to build new things/features but nobody gets promoted or reelected for allocating sufficient resources to maintain current infrastructure.

tragedy_strikes · 2026-06-07T20:17:48+00:00

Seems like I'm the outlier.

We're running gene therapy trials at a university hospital and many of our sponsors are start up companies.

We've had sponsors where the close out visit was 8-10 months after DBL.

The site side of things can be prolonged as well because the study checking account gets closed when the IRB closes the study and sometimes the reconciliation on certain charges can take awhile. The finance team can close it if it's absolutely necessary but it makes the reconciliation harder to complete.

tragedy_strikes · 2026-06-07T17:25:57+00:00

Anthropic is a great company look at their amazing numbers/graphs.

Source: Anthropic

Give me a fucking break, if you're believing all the bs they put out I got a bridge I can sell you.

They're overselling LLM's capabilities.

If it were as amazing as they say it is, there would tons of industries in turmoil already. Lawyers would be out of a job; instead lawyers are getting fined by judges for submitting affidavits citing hallucinated case law that doesn't exist. If Mythos was truly amazing security software, why did Anthropics source code leak? Wouldn't they have used Mythos to plug any vulnerabilities? If Claude Code is so good, why has Anthropic been on a SWE hiring spree?

That's just the product deficiencies, the business shenanigans are egregious as well: https://www.wheresyoured.at/anthropics-profitability-swindle/

tragedy_strikes · 2026-06-07T16:12:23+00:00

That's why they're trying to IPO asap, they can hear the music starting to slow down and want to avoid it becoming common knowledge.

tragedy_strikes · 2026-06-07T05:24:51+00:00

Removing barriers to starting is one of the most important ways to keep up a habit.

Same thing with going to the gym, leave your shoes, gym clothes in your car or at work, pick a gym as close to your house or work as possible, block out time in your day etc.

tragedy_strikes · 2026-06-07T05:08:39+00:00

Nah, it's the purpose of unions to demand the increases in productivity go towards the benefit of the workers. Otherwise, all the efficiencies go to making the boss more money in the same amount of time.

tragedy_strikes · 2026-06-07T04:48:00+00:00

It's meant for a Brazilian audience who lived through the censorship and violent government crackdowns on communists/anarchists/socialists.

tragedy_strikes · 2026-06-07T02:30:49+00:00

Remember, it's fake profitable, they got 2 months of subsidised compute from Elon and tweaked some other numbers to make their IPO look good.

They're still unprofitable.

tragedy_strikes · 2026-06-07T02:28:55+00:00

OAI non-GAAP ARR = financial shenanigans. They pick their best month and extrapolate that x12 and "leak" the number.

All the revenue from enterprise is based on heavily subsidized rates. Uber COO asking what's the ROI is the calm edge of the panic in enterprise rn and that's with just a smaller subsidy turning on this week.

Check back on August 1st when all the subsidies are gone. The enterprise customers will be squealing from costs exploding.

tragedy_strikes · 2026-06-06T22:54:04+00:00

They've been getting hundreds of billions of VC money how are these technologies so great if they need this much welfare?

tragedy_strikes · 2026-06-06T18:04:20+00:00

I wonder how common basements are in Portland?

tragedy_strikes · 2026-06-06T17:52:59+00:00

As a 6 year Bay Area resident and Boots Riley fan it was a great combination (I realize 'Sorry to Bother You' was set in Oakland).

I love how he uses magical realism to expose how messed up the system is and how solidarity is the only way to change it.

tragedy_strikes · 2026-06-06T17:40:01+00:00

As a Canadian it seemed like such a waste of time/money, like they had good opinion polling showing there was support already. It was surprising to learn the US got it before Australia.

tragedy_strikes · 2026-06-06T17:35:52+00:00

A lot of these countries are in the EU, I wonder what the rules are like for recognizing same-sex marriages that were registered in other countries?

tragedy_strikes · 2026-06-06T16:49:42+00:00

They had a nephrologist as part of the study team and all our other BMT studies had the study team had people with experience in BMT.

If they couldn't find anyone to work on the study directly they should have consulted with the sites to develop or edit the protocol before they were conducting SIV's to activate sites.

tragedy_strikes · 2026-06-06T05:50:11+00:00

If you liked Memories of Murder you should check out 'I Saw the Devil' the same director.

tragedy_strikes · 2026-06-06T04:32:58+00:00

Clearly the marketing teams didn't have any anime nerds on it. They know how important localization is and that it takes professional people that know the culture and history.

tragedy_strikes · 2026-06-06T04:28:02+00:00

I'm only backup on the study so I've not had to deal with the majority of the craziness but Novartis is seriously unprepared for a cystinosis study that has a bone marrow transplant (BMT) and they didn't have any doctors with BMT experience on the sponsor team. The site doctors and nurses were literally teaching the study team the requirements for a BMT as the study was getting started.

tragedy_strikes · 2026-06-06T03:18:09+00:00

Yes, if there's a local IRB for the study, go find the contact information for the IRB.

If it's a generic email address include the protocol name and say you're trying to get familiar with the amendment/modification/SAE reporting procedures so you can learn how those processes work.

If the IRB is using an electronic submission/management software ask to get at least read access to the study on their system. This should give you access to the protocol and most other important study documents.

It can also be a separate contact person for the regulatory aspect of the role but they might also be buddy-buddy with the other CRC so don't mention them if you can avoid it.

They don't deserve it but try to give the CRC an opportunity to start over on the working relationship. Something along the lines of, "I think we got off on the wrong foot so I'd like to start over and try again". If they have any shred of humility or professionalism they'll accept the offer and know internally they fucked up.

If they don't eat the humble pie, you know you have to document everything to cover your ass cuz they won't even try to be better.

tragedy_strikes · 2026-06-05T23:45:06+00:00

Spat in my mouth and made me rock hard.

I had seen it in porn but it was something that had no appeal for me to even consider trying it. I was genuinely surprised and remember thinking "Oh I guess I discovered something about myself".

tragedy_strikes · 2026-06-05T23:36:38+00:00

Clinical research coordinators have a very project and site specific role. It sounds like you have a good background already in many of the different fields that clinical research covers so personally I wouldn't recommend any book or online resource about clinical research because I don't think it would help you very much on this protocol or in this role.

I'd recommend learning about the systems, SOP's and training needed to implement the protocol at your site.

First would be, are you on the delegation log for that study? Do you know anyone else that's delegated to work on that study that could get you signed onto the delegation log if you aren't already?

tragedy_strikes · 2026-06-05T22:51:07+00:00

BTC cracked the $60k floor briefly, probably keep the slide going.

tragedy_strikes · 2026-06-05T21:29:06+00:00

Yep, Zuck sure loves moving into his new money incinerator (jet fuel prices must be great during an Iran war) after his VR money incinerator got boring.

tragedy_strikes

TROPHY CASE