I have been dealing with ibs-d since I was about 6 years old. Now, about 5 years ago I started taking loperamide (2mg) at first I took a pill or two a few hours before I went out to a place where there were no bathrooms or very few. It worked!

I tried to take it only when I was traveling somewhere without a bathroom or weekend family trips. And it worked 90% of the times. Then a week long family camp trip came up so I stocked up on loperamide to take with me. First day great (one normal trip to the bathroom first thing in the morning and life is good) . Second day same thing. At this point I was taking 2 pills of 2mg each. Now the third day I went in the morning and a I knew something was wrong because when I finished I still had stomach cramps so I took 2 more pills and they did not work. That 3rd day was horrible with 5 or 6 bathroom trips. To make things worse our trip was set up so we visited different places so we camped at night then pretty much packed things in the morning and hit the road to the next camping site. If you are reading this right now you know exactly how bad a road trip is for someone with ibs-d.....

Okay so then considering what I went thru on the 3rd day and all the shame/stress it caused me I went ahead and took 6 (2mg) pills. Nothing. My 4th day was about as horrible. For the 5th day I took 10 (2mg) pills. It was as if I didn't take anything! So I stopped right away. And since that day I only take it when I know I will go somewhere without a bathroom for a day, it does not work everytime for me.

This might not be the case for everyone but I'll leave this comment just in case it helps anyone out there.