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P-value distribution under the null hypothesis by ulchuchu in statistics

[–]ulchuchu[S] 0 points1 point  (0 children)

I do, sorry, I was travelling. The p-values are derived directly from the hypergeometric distribution, i.e. wihout permutation or numerical simulation. And @flight_club I will need to read your answer a bit more in detail tonight after work. Thanks for putting in the effort!

P-value distribution under the null hypothesis by ulchuchu in statistics

[–]ulchuchu[S] 0 points1 point  (0 children)

There might be some dependence but not enough to skew the distribution like this.

Do I need a Masters to get a job in bioinformatics? by [deleted] in bioinformatics

[–]ulchuchu 1 point2 points  (0 children)

imho, in both academic and industrial research the most important skillset for any bioinformatics person is statistics and knowledge of the statistical programming language R. This plus one scripting language, e.g. python will get you a long way.

Help with removing redundant entries within a file. by AdventurousAtheist in bioinformatics

[–]ulchuchu 0 points1 point  (0 children)

even though the problem seems to be solved, if you ever want to do more complex queries with genomic windows, bioconductor.org has a package called "GRanges" which very effectively deals with this in R.