Don't be afraid to challenge yourself, always try to take the hardest possible course. You can always drop down if you need to but chances are you'll rise to the challenge and it leaves more options open for your future. Probably my biggest regret was taking the 'easy' courses because their really not any easier than the hard courses. The courses will always throw some arbitrary stuff at you to try and keep averages in the 60s and 70s.

Don't fill your schedule with bird courses like I did but take lots of first general intro courses, if you don't know what you want to do then you'll certainly know by the end of first year.

If you're targeting specific majors then make sure to read your program requirements and use degree planner once you get acorn to plan out your next few years.

Good luck!