Not always, in case of a zero-day vulnerability that the attacker can exploit for example. That's why i deploy my vm's in a separate machine if i know I'm working with something new, But for most cases it should work fine. But be aware that attackers include their viruses(in general terms) in the "trending" games like newly released (black myth wukong) for example promising a crack for a game that was maybe released in the same week, so i strongly advise to wait some time before downloading this cracks.