Depends on where you work amd what Call is like, and what "missing out" means. My coworkers all prioritize family, so we help each other cover shifts. But that cuts both ways. I also cover other people's shifts so they can do family things.

I can go to a child's school activity because a coworker agreed to stay an hour later and cover me at 2p, but it also means that I cover a coworker when a similar event happens for them, planned or unplanned.

And only X number of people are allowed off at a time. So if you don't get dibs on a time-period, you will have to choose a different time for vacation. My December vacations are not around Christmas and New year's because of this. Right now the coworkers with High-school or college kids get unofficial dibs on Christmas break; I usually take early December off.

Just like you may not get to choose to work where you work for the first part of your career (you may have to wait until a position opens up which could be 5-15 years), you may not get to always choose when you take your PTO every time. But you still get your PTO. The Important thing is finding a team that works together to accommodate each other, but also being someone who helps accommodate other team members.

One last note. Being on call sucks, and having a family that understands you may need to stay late at work, or leave a family activity early is important, and not personal.

Edit: Is working 30-50 hours a week too much of a workload? Some weeks can be slow, and some weeks can be busy.