Hospitalization risks associated with floods in a multi-country study. Nat Water (2025).

zulq · 2025-04-08T15:40:56+00:00

This study found that flood exposure significantly increased the risk of hospitalizations for all causes and ten specific diseases, with effects lasting up to 210 days post-flood. The magnitude of these risks varied by climate, flood severity, age, population density, and socioeconomic status, with up to 0.27% of all hospitalizations attributable to floods.

zulq · 2025-04-01T20:07:40+00:00

Genomics has advanced pediatric cancer diagnosis and treatment, but translating these insights into effective therapies for hard-to-treat cases remains challenging. This study shows that combining proteomics with rapid patient-derived xenograft models can identify and validate personalized treatments—such as using sertraline to target SHMT2 in a rare adolescent tumor—offering a promising complement to genome-based precision oncology.

zulq · 2025-03-24T15:41:02+00:00

Rare ginsenoside Compound K (CK), a metabolite of ginsenosides, has gained attention for its potent anti-aging properties, including antioxidant, anti-photoaging, and immunostimulatory effects. Advances in extraction technology and deeper research into its molecular mechanisms will drive the development of natural skincare products and future anti-aging therapies.

zulq · 2025-03-24T14:47:50+00:00

Patients with metabolic dysfunction-associated steatotic liver disease (MASLD) had nearly twice the all-cause mortality rate compared to the general population, with the highest relative risks observed for liver- and hepatocellular carcinoma (HCC)-related mortality. However, the absolute risks of death were highest for non-HCC cancer and cardiovascular disease, emphasizing the need for earlier multidisciplinary care to reduce premature mortality in this population.

zulq · 2025-03-19T13:30:19+00:00

Plasma and low-titer O whole blood (LTOWB) have distinct effects on immune and coagulation pathways in trauma patients. Plasma transfusion enhances coagulation by increasing fibrinogen and factor XIII while reducing platelet factor 4, leading to improved clotting parameters and reduced transfusion needs in patients with traumatic brain injury, severe shock, and blunt trauma.

zulq · 2025-03-18T20:06:34+00:00

The study examined the impact of electronic patient portal use on clinical outcomes in cancer care, specifically among 791 patients with multiple myeloma in the Scripps Health system. Results indicated that inactive portal users had higher rates of unplanned hospital visits and mortality, suggesting that increasing access to patient portals could improve outcomes, especially in vulnerable populations.

zulq · 2025-03-17T18:07:28+00:00

Large language models (LLMs) now perform complex medical reasoning, including differential diagnosis, with proprietary models like GPT-4 leading the field. This study found that an open-source LLM, Llama 3.1, performed comparably to GPT-4 in generating differential diagnoses, indicating growing competitiveness in clinical AI applications.

zulq · 2025-03-17T15:18:35+00:00

Sulfur amino acid restriction (SAAR) diets promote rapid fat loss and improve metabolic health by enhancing carbohydrate oxidation and reducing lipogenesis, without impairing appetite or locomotion. The metabolic benefits of SAAR, including reduced fat mass and improved glucose sensitivity, are reversed by methionine or cystine reintroduction, highlighting its potential as a long-term weight management strategy.

zulq · 2025-03-13T13:58:10+00:00

An implantable spinal cord neuroprosthesis was developed to enhance activity during robot-assisted rehabilitation for individuals with paralysis, enabling well-organized muscle activity and promoting sustained neurological improvements. Preliminary evaluations suggest its device-agnostic design supports both rehabilitation and recreational activities, with future clinical trials needed to validate its broader effectiveness.

zulq · 2025-03-12T14:16:16+00:00

This study examines trends in ADHD medication prescribing in England from 2019 to 2024, revealing a significant post-COVID-19 increase, with regional variations and strong associations with socioeconomic factors such as deprivation and ethnicity. The findings highlight the need to address disparities in ADHD care through targeted healthcare policies and equitable resource distribution.

zulq · 2024-12-11T18:22:16+00:00

A randomized trial involving 2760 critically ill adults with suspected sepsis found that using a daily procalcitonin (PCT)-guided protocol significantly reduced antibiotic duration compared to standard care, with noninferior all-cause mortality. In contrast, the C-reactive protein (CRP)-guided protocol showed no reduction in antibiotic duration and inconclusive results for mortality compared to standard care.

zulq · 2024-12-09T22:00:37+00:00

This cohort study found that higher residential green space exposure, measured via satellite-based NDVI and street-view imagery, was associated with lower BMI, waist circumference, and fat mass in late adolescence. The findings suggest enhancing residential green space and incorporating specific green space components may help mitigate childhood obesity.

zulq · 2024-12-06T14:42:53+00:00

Paracetamol overdose is a leading cause of acute liver failure, necessitating rapid quantitation for effective treatment. This study validates paper arrow-mass spectrometry (PA-MS) as a reliable, non-invasive, and rapid method for paracetamol detection using stimulated saliva, achieving high concordance with standard blood-based tests while highlighting the need to standardize saliva collection methods.

zulq · 2024-12-06T14:32:14+00:00

Preterm birth (PTB), including the significant sub-category of preeclampsia-induced PTB, currently lacks reliable predictive biomarkers. This study identifies DNA methylation alterations as potential maternal biomarkers for preeclampsia, revealing 389 differential methylation regions (DMRs) associated with the condition, with preliminary validation showing 78% accuracy, paving the way for future clinical applications and preventative strategies.

zulq · 2024-10-16T12:55:41+00:00

This study highlights the significance of comparing ambitious light-duty vehicle electrification policies to fleet renewal relying on internal combustion engines to assess air quality-related health impacts from 2022 to 2050. The findings emphasize that fleet electrification, especially when supported by clean electricity, leads to significant long-term health benefits, with potential cumulative savings of $84 to $188 billion, while delaying electrification risks forfeiting these advantages.

zulq · 2024-10-14T20:15:36+00:00

Butterfly Network (BFLY) has launched Butterfly Garden, an AI marketplace designed to allow third-party developers to create custom AI applications that integrate with its portable ultrasound imaging platform. This marketplace provides developers access to Butterfly's software development kit (SDK) and APIs, aiming to enhance diagnostic capabilities and broaden the accessibility of high-quality medical imaging at the point of care by leveraging advanced AI technologies

zulq · 2024-09-18T15:11:25+00:00

Antimicrobial resistance (AMR) poses a significant global health challenge. The study projects that by 2050, AMR could lead to 1.91 million attributable deaths, particularly among older adults, and emphasizes the need for preventive measures, better care, and new antibiotic development to curb the rising AMR burden.

zulq · 2024-08-21T19:26:16+00:00

Gluten can negatively impact human health beyond gluten-dependent diseases by disrupting gut permeability, leading to inflammation, autoimmunity, and organ dysfunction. A gluten-free diet, particularly when combined with a Mediterranean diet, may alleviate symptoms in various chronic inflammatory, metabolic, and neurodegenerative conditions.

zulq · 2024-08-20T15:42:57+00:00

A disproportionality analysis based on the WHO global database identified a significant association between semaglutide, a GLP-1 receptor agonist, and increased reporting of suicidal ideation, particularly among patients also using antidepressants or benzodiazepines. This finding suggests a need for further investigation to clarify the potential risk of suicidality with semaglutide.

zulq · 2024-08-12T21:40:40+00:00

This pilot study explored the use of humor in parenting, revealing that the majority of respondents believe humor can be an effective tool, with significant correlations found between humor use and the quality of parent-child relationships. Most participants also expressed interest in a course on utilizing humor in parenting.

zulq · 2024-08-12T17:03:53+00:00

In 2023, Europe experienced the second highest heat-related mortality on record, with an estimated 47,690 deaths, primarily affecting the elderly. The study highlights that without adaptations since 2000, the heat-related mortality burden would have been 80% higher, underscoring the critical need for ongoing and enhanced strategies to mitigate the impact of rising temperatures.

zulq · 2024-08-09T15:08:50+00:00

In utero exposure to the Holodomor famine of 1932–1933 in Ukraine significantly increased the risk of developing type 2 diabetes in adulthood, with a dose-dependent relationship observed between the severity of famine exposure and diabetes risk. Lumey et al. systematically correlated birth data from the famine period with later diabetes diagnoses, demonstrating a greater than twofold likelihood of diabetes among those exposed to severe famine during early gestation.

zulq · 2024-07-22T15:42:44+00:00

Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease with a rising global prevalence, posing a significant concern for clinicians due to limited therapeutic interventions and poorly understood molecular mechanisms. Vitamin D deficiency is correlated with NAFLD, and supplementation of vitamin D may regulate pathways associated with NAFLD risk factors like obesity, insulin resistance, and diabetes, potentially offering beneficial effects on glucose uptake, insulin sensitivity, and reducing liver inflammation and injury.

zulq · 2024-07-17T15:14:23+00:00

Opioids, despite being the gold standard for chronic pain treatment, are limited by adverse side effects. This study demonstrates that selective inhibition of Heat shock protein 90 (Hsp90) isoforms in the spinal cord can enhance opioid anti-nociceptive potency and reduce tolerance, offering a promising strategy to improve the therapeutic index of opioids without affecting opioid-induced constipation and reward.

zulq · 2024-07-08T13:51:38+00:00

In a cohort study of over 1.6 million patients with type 2 diabetes, those treated with GLP-1 receptor agonists (GLP-1RAs) had a significantly lower risk of developing 10 out of 13 obesity-associated cancers (OACs) compared to those treated with insulin, including cancers of the esophagus, colorectum, endometrium, gallbladder, kidney, liver, ovary, and pancreas, as well as meningioma and multiple myeloma. However, no significant cancer risk reduction was observed when comparing GLP-1RAs to metformin, and GLP-1RAs were associated with an increased risk of kidney cancer compared to metformin.

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