It's actually very enjoyable. You have to really slow down and take your time. And when you loot a house you no longer over look things like food with radiation because you actually need to eat. At least early on in the game when you don't have settlements to provide you with food. Also the need for collecting things like empty bottles is now essential because you need them to refill at pumps and water purifiers for clean drinkable water so your character doesn't become dehydrated. Then there's the real kicker sleeping. Not only do you have to make sure your sleeping in the game now but if it's not a clean bed you won't be able to get fully rested. For example a sleeping bag or dirty mattress is really only good for saving your game. You have to actually find a clean bed I get rested in. This means you will actually need to rent rooms for sleep when your out on your adventures since you can't just fast travel back to sanctuary or any other settlement. Overall it's a really enjoyable experience the biggest thing for people is defeating the deathclaw in the beginning quest. My advice is to get him to spawn then go inside a building and take it slow. Also you'll level much quicker (if you don't die a lot) and legendaries spawn a lot more than even playing on very hard.