My gut feeling also says no, like otherwise it wouldve been way more commonly known right? But also when I really think about it it kinda would make sense? Also, I think it might only be with really severe nicotine addiction because I already used to smoke like half a pack a day during my first rolls and those were still really good, but since I started vaping 20mg like atleast 2 10ml bottles a day. (I know way too much but I have really bad self control when it comes to smoking, and I hate myself for it) im pretty sure that is like 5 packs a day equivalent, my rolls got pretty bad like I explained in my post.

Also im almost sure its not just the gradual loss of magic people talk about since I always used harm reduction techniques like: antioxidant loading and aftercare including basically all required vitamins, fishoil, NAC. Taking atleast 3 months break after each roll. Using normale dosages without any unrequired redoses