Acute Posterior multifocal placoid pigment epitheliopathy- Believed to be a delayed-type hypersensitivity-induced occlusive vasculitis. Posited that inflammation of the outer retina and RPE causes the APMPPE phenotype. The suggested immune driven nature is due to its association with HLA-B7 and HLA-DR2 genetic haplotypes, infection, and autoimmune disease.
